Denoising Local Field Potentials from Electrocardiography Artifacts
Objective: An algorithm to reliably detect and suppress the QRS complexes of the Electrocardiography (ECG) activity contaminating the Local Field Potentials (LFP) recorded via Implantable…A metadata-driven tool to determine the robustness of digital health technologies assessments for Parkinson’s disease leveraging the voice of the patient
Objective: To develop a decision tool for assessing the robustness of digital health technology (DHT)-based measures in Parkinson’s disease (PD) using a patient-centric approach. Background: Development of effective therapeutics in PD is hampered by the lack of drug development…Open-Source Tremor Tracking for MR-guided Focused Ultrasound (MRgFUS): An Objective Approach for Monitoring Treatments
Objective: To describe a novel system developed for real-time noninvasive monitoring of treatment efficacy in patients undergoing MR-guided Focused Ultrasound (MRgFUS) treatment for refractory tremor.…Slow Motion Analysis of Repetitive Tapping (SMART) test: measuring of bradykinesia in recently diagnosed Parkinson’s disease and idiopathic anosmia
Objective: To develop a quantitative method to track repetitive finger tapping movements and to compare people in the early stages of Parkinson’s disease (PD), healthy…Effect of dopaminergic treatment on digital sensor features in Phase II PASADENA Part 1 in early Parkinson’s disease
Objective: To characterize the sensitivity of smartphone and -watch sensor features to levodopa and dopamine agonist (DA-Tx) treatment. Background: Digital health technology tools (DHTTs) enable…Development of quantitative tools for in-home clinical assessment of people with Parkinson’s disease
Objective: To develop telehealth digital data collection methods for evaluation of multi-modal function in people with Parkinson’s Disease (PwPD) and develop biomedical informatics tools for…Evaluating the use of digital biomarkers to test treatment effects on cognition and motor in patients with Lewy Body Dementia
Objective: To evaluate if frequent cognitive and motor tests using an iPad app and a wrist-worn actigraphy watch to track activity and sleep can detect…Novel quantitative measures with standardised graphical tasks to objectively assess subtle changes in fine motor skill in diagnosing and monitoring of Parkinson’s disease
Objective: To integrate a handheld device with standardised graphical tasks into clinical assessment for automated objective motor symptoms rating with digital record keeping in Parkinson’s…Accelerometry to optimize optical flow measurement of repetitive finger tapping movements: A pilot study
Objective: To optimize optical flow (OF) measurement of repetitive finger tapping movements with the use of concomitant accelerometry in healthy volunteers. Background: Repetitive finger tapping…Tissue-engineered nigrostriatal pathway to rebuild dopaminergic axons in Parkinson’s disease based on clinical design criteria
Objective: To create a tissue-engineered construct with the dopaminergic (DA) cell numbers, axon lengths, and functionality required to reconstruct the human nigrostriatal pathway (NSP). Background:…
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