Integrating Transcriptomics and Morphological Profiling to Characterize GBA-Associated Parkinson’s Disease in Midbrain Organoids
Objective: This study characterizes converging biological trends in GBA-associated Parkinson’s Disease by integrating transcriptomic profiling with exploratory image-based analysis of donor-matched midbrain organoids. Background: High-content…Therapeutic Efficacy of a Next-Generation 16-Contact Directional Deep Brain Stimulation System in Parkinson’s Disease
Objective: We assessed the clinical efficacy and safety of a novel deep brain stimulation (DBS) system equipped with 16-contact directional leads in improving motor symptoms…Modeling the Genetic Complexity of Parkinson’s Disease: Generation of Patient-Specific iPSCs with Co-occurring SNCA/GBA1 and PRKN/LRRK2 Variants
Objective: This study aimed to generate and characterize human induced pluripotent stem cell (iPSC) lines derived from two Parkinson’s Disease (PD) patients carrying combinations of…Early-Onset Parkinson’s Disease with Early Peak-Dose Dyskinesia: A Case Report
Objective: To present a case of early-onset Parkinson's disease (EOPD) in a 41-year-old male with good levodopa response but complicated by early development of peak-dose…Evaluating YouTube as a source of health information on Parkinson’s disease
Objective: This study aimed to evaluate the quality, reliability, and engagement characteristics of YouTube videos on Parkinson's disease using standardized assessment tools. Background: Parkinson’s disease…Feasibility of Remote Identification of Catatonia Across Different Motor Presentations
Objective: To evaluate the feasibility of the identification of catatonia by trained raters through remote viewing of motor assessments across patients with differing motor profiles…Prevalence and associated factors of sarcopenia among Thai patients with ambulatory Parkinson’s disease
Objective: Objectives: To determine the prevalence of Asian Working Group for Sarcopenia (AWGS) 2019-defined sarcopenia phenotypes, identify associated factors, and evaluate screening performance in Thai PD patients. Background: Sarcopenia is…Healthcare Professionals’ Perceptions of using eHealth in the Rehabilitation of Progressive Disease: A Qualitative Study
Objective: This study aimed to explore the perceptions of occupational therapists and physical therapists, working in primary care settings, concerning the use of eHealth methods…Neuropsychiatric Symptom Evolution Over the First Decade of Biomarker-Defined Parkinson’s Disease
Objective: To examine the evolution of neuropsychiatric symptoms (NPS) in biomarker-defined Parkinson’s disease over the first decade following diagnosis. Background: Parkinson’s disease (PD) is frequently…Opicapone as adjunct to levodopa in Chinese patients with Parkinson’s disease and wearing-off: a randomized, double-blind, placebo-controlled phase 3 trial
Objective: To evaluate the efficacy and safety of once-daily opicapone as adjunct to levodopa in Chinese patients with Parkinson’s disease (PD) and wearing-off, and to…
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