Efficacy and Safety of Mesdopetam (IRL790) for Levodopa Induced Dyskinesia in Parkinson’s Disease: A Meta analysis of Randomized Controlled Trials
Objective: To evaluate the efficacy and safety of mesdopetam compared with placebo for levodopa‑induced dyskinesia (LID) in Parkinson’s disease (PD). Background: Mesdopetam (IRL790) is a…Cerebrospinal Fluid Metabolic Alterations Reveal a Central Energy Metabolism Shift in Parkinson’s Disease
Objective: To comprehensively characterize central energy metabolism in Parkinson’s disease (PD) through cerebrospinal fluid (CSF) metabolomic profiling. Background: We previously reported weight loss and systemic…Posterior tibial nerve Stimulation in the management of Urinary Disorders in Parkinson’s Disease Experience of the National Hospital Center of Pikine
Objective: Evaluate the efficacy of posterior tibial nerve stimulation in the management of LUTS in patients with PDCompare posterior tibial nerve stimulation to medication Background:…When Muscles Relax but Symptoms Persist: A Case of Dysfunctional Sensory-Motor Cortical Integration in Botulinum Toxin-Resistant Blepharospasm
Objective: To present a case of blepharospasm (BSP) with objective response to serial botulinum toxin injections but persistent subjective symptoms, highlighting the role of sensory…PPP2R5D Variants in Patients Diagnosed With Parkinson’s Disease. A Large‑Scale Multi‑Cohort Analysis
Objective: To identify individuals with rare pathogenic and potentially pathogenic variants of unknown significance (VUS) in PPP2R5D within large Parkinson’s disease (PD) cohorts, to characterize…Effects of Immersive Gamification Technology on the Physical Function of People with Parkinson’s Disease: A Scoping Review
Objective: This scoping review serves to provide an overview of the methods and effects of different ImGTS on various aspects of physical function (e.g., balance,…Neuropsychiatric Symptom Evolution Over the First Decade of Biomarker-Defined Parkinson’s Disease
Objective: To examine the evolution of neuropsychiatric symptoms (NPS) in biomarker-defined Parkinson’s disease over the first decade following diagnosis. Background: Parkinson’s disease (PD) is frequently…Evaluating Magnetic Resonance Parkinsonism Index (MRPI) and MRPI 2.0 as Radiographic Metrics to Differentiate Progressive Supranuclear Palsy (PSP) from Normal Pressure Hydrocephalus (NPH)
Objective: We analyze the discriminatory diagnostic value of the Magnetic Resonance Parkinsonism Index (MRPI) and MRPI 2.0 in progressive supranuclear palsy (PSP) and normal pressure…Nigrostriatal Dopaminergic Impairment Patterns in Idiopathic Normal Pressure Hydrocephalus Identified by 18F-FP-DTBZ PET: a 5-Year Longitudinal Study
Objective: To delineate the pattern of nigrostriatal dopaminergic dysfunction in iNPH, explore inter-individual heterogeneity, and evaluate its association with clinical features and long-term outcomes. Background:…Clinical and Autonomic Correlates of Chronic Sialorrhea in Parkinson’s Disease: A Questionnaire-Based Study with Cluster Analysis of Autonomic and Dysphagia Burden
Objective: To examine factors associated with drooling in patients with Parkinson’s disease (PD), patient awareness and perceptions of botulinum toxin therapy, and the relative contributions…
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