Quantitative Analysis of Oculomotor Abnormalities in Parkinson’s Disease
Objective: To quantitatively characterize oculomotor abnormalities in patients with Parkinson’s disease (PD) and to evaluate their potential utility for assessing oculomotor dysfunction and supporting early…Rare Neurotoxicity of Cotrimoxazole A Movement Disorder Presentation In Elderly Patient
Objective: We report the case of an elderly woman with hyperkinetic movement disorders Background: Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used for Pneumocystis jirovecii prophylaxis, but significant neurological toxicity…Modeling the Genetic Complexity of Parkinson’s Disease: Generation of Patient-Specific iPSCs with Co-occurring SNCA/GBA1 and PRKN/LRRK2 Variants
Objective: This study aimed to generate and characterize human induced pluripotent stem cell (iPSC) lines derived from two Parkinson’s Disease (PD) patients carrying combinations of…Neurophysiologic Testing Aids Diagnosis of Stiff-person Spectrum Disorders
Objective: To develop standardized, quantifiable criteria when using neurophysiologic techniques to diagnose SPSD. Furthermore, we desired two levels of diagnostic certainty: Neurophysiology Possible for high…Late-Onset Ataxia, Tremor and Spastic Paraparesis associated with the a Novel CCDC88C Variant: Expanding the Phenotypic Spectrum of mutation in the CCDC88C gene
Objective: to describe a Croatian family presenting with late-onset spastic paraparesis and cognitive decline associated with a distinct amino acid substitution. Background: Variants in CCDC88C…Prognostic Impact of GBA Variants on Mortality in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: This systematic review and meta-analyses aim to synthesize longitudinal evidence of GBA variants as a prognostic factor for all-cause mortality in Parkinson’s disease (PD).…Cerebrovascular reactivity in Parkinson’s disease: acute effects of Levodopa assessed by transcranial doppler
Objective: To evaluate CVR in people with PD (pwPD) and its acute modulation after Levodopa administration. Background: Parkinson’s disease (PD) is associated with neurovascular unit…Extended long-term follow-up of adaptive deep brain stimulation in Parkinson’s disease
Objective: To evaluate the extended long-term durability, programming stability, and safety of adaptive deep brain stimulation (aDBS) in people with Parkinson’s disease (PD). Background: Adaptive DBS is a recently available enhancement to continuous DBS (cDBS) that dynamically adjusts stimulation amplitude based on neural…Adaptive Subthalamic Nucleus Deep Brain Stimulation (aDBS) for Refractory Dyskinesia in Parkinson’s Disease: A Case Report of Two Patients
Objective: This is a case report of two patients to using adaptive subthalamic nucleus deep brain stimulation (aDBS) for refractory dyskinesia Background: Although continuous subthalamic…Exploring the Relationship Between Circadian Disruption, Depression and Suicidal Ideation in People with Huntington’s Disease (Mind & Clock Study)
Objective: To examine the relationship between circadian and sleep disruptions and depressive symptoms and suicidal ideation in people with Huntington’s Disease (PwHD) using scale-based and…
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