Validation of Augmented Reality–Based Speech Biomarkers for Objective Detection and Monitoring of Parkinson’s Disease and Atypical Parkinsonian Syndromes
Objective: To validate the feasibility and diagnostic potential of an offline, head-mounted augmented reality (AR) system for automated extraction of acoustic and temporal speech biomarkers in…Acupuncture Combined with Anti-Parkinson Medication Improves Objective Balance Parameters in Patients with Parkinson’s Disease
Objective: To evaluate whether acupuncture combined with anti-Parkinson medication improves balance in patients with PD. Background: Parkinson's disease (PD) frequently causes balance dysfunction in older patients.…Skin Biopsy for Phosphorylated Alpha-Synuclein and DAT Imaging in Patients Diagnosed with Psychogenic Parkinsonism
Objective: Objective:Describe the results of skin biopsy for phosphorylated alpha-synuclein (P-SYN) and dopamine transporter (DAT) imaging in patients previously diagnosed with psychogenic parkinsonism (PP) and…Adaptive Subthalamic Nucleus Deep Brain Stimulation (aDBS) for Refractory Dyskinesia in Parkinson’s Disease: A Case Report of Two Patients
Objective: This is a case report of two patients to using adaptive subthalamic nucleus deep brain stimulation (aDBS) for refractory dyskinesia Background: Although continuous subthalamic…Multimodal Deep Learning for Parkinson’s Disease Screening: Fusing Quantitative Gait Analysis and Clinical Features
Objective: To develop and validate a machine learning model integrating quantitative gait parameters and clinical features to enhance the diagnostic accuracy of Parkinson's disease (PD)…Effects of Modafinil on Motor and Non‑Motor Outcomes in Parkinson’s Disease: A Meta‑Analysis of Randomized, Placebo‑Controlled Trials
Objective: To determine the efficacy and safety of modafinil on motor and non-motor outcomes in Parkinson’s disease (PD) using evidence exclusively from randomized placebo‑controlled clinical…Effects of Botulinum Toxin Therapy on Depression, Anxiety, Pain, and Quality of Life in Patients with Dystonia
Objective: To evaluate changes in depression,anxiety,pain, and quality of life alongside motor improvement in patients with dystonia treated with botulinum toxin(BoNT). Background: Dystonia is a…Pesticide Exposure and Motor Severity in Parkinson’s Disease in a Mexican Population: A Retrospective Longitudinal Cohort Study
Objective: To evaluate whether pesticide exposure is associated with greater baseline motor severity and accelerated longitudinal motor progression in Mexican patients with Parkinson’s disease (PD).…Online Assessments Measure Motor and Cognitive Progression in People with and without Parkinson’s Disease
Objective: To evaluate longitudinal progression in online participant reported outcomes (PROs) among people with Parkinson’s disease (PD), prodromal PD, and healthy controls. Background: Collecting PROs…Gut Microbiome Metagenomics in Parkinson’s Disease Stratified by the Asian-Prevalent LRRK2 Variants p.G2385R and p.R1628P
Objective: To compare gut microbiome profiles of manifesting LRRK2 p.G2385R or p.R1628P carriers (LRRK2-PD) and idiopathic Parkinson’s disease patients (iPD). Background: Leucine-rich repeat kinase 2…
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