PPP2R2B Splice Variant Dysregulation Promotes Mitochondrial Association and Neuronal Apoptosis in iPSC-Derived Neurons from Spinocerebellar Ataxia Type 12 Patient
Objective: This study aimed to investigate the impact of PPP2R2B mutation in Spinocerebellar Ataxia Type 12 (SCA12) by analysing PPP2R2B splice variant expression, subcellular localization,…Emergence of Cortical Amyloid from the Prodromal Stage of the Lewy Body Disease Spectrum: Evidence from a PiB-PET Study
Objective: To characterize β-amyloid (Aβ) deposition across the Lewy body disease (LBD) spectrum using Pittsburgh compound B positron emission tomography (PiB-PET) and examine the influence…Parkinson’s Disease and Osteoporosis Comorbidity: A Bibliometric Analysis and Exploration of Mechanistic Pathways and Key Genes
Objective: Explore the association between Parkinson’s disease (PD) and osteoporosis (OP). Background: In recent years, PD and OP have emerged as significant global public health burdens[1,…Subtle Behavioral Changes Observed by Knowledgeable Informants Up to Decades Before Parkinson’s Disease Diagnosis
Objective: To characterize subtle behavioral changes observed by Knowledgeable Informants (KIs) of people with Parkinson’s disease (PwPD) before diagnosis. Background: Earlier identification of PD remains…Wearable-Derived Gait Biomarkers Predict Disease Severity and Quality of Life in Parkinson’s Disease: A Machine Learning and Mediation Analysis
Objective: To investigate whether wearable-derived gait biomarkers predict disease severity and health-related quality of life in Parkinson’s disease (PD) and to examine the mediating role…Longitudinal Decline of Alanine Aminotransferase Activity in Parkinson’s Disease and Its Association with Disease Duration
Objective: To characterize longitudinal trajectories of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and the neutrophil-to-lymphocyte ratio (NLR) in Parkinson’s disease (PD) and healthy…Preservation of Cognition Following Intravenous Mesenchymal Stem Cell Therapy in Parkinson’s Disease: Secondary Analysis of a Randomized Trial
Objective: To evaluate longitudinal changes in global cognition following intravenous allogeneic bone marrow–derived mesenchymal stem cell (allo-hBM-MSC) therapy in Parkinson’s disease (PD). Background: Cognitive impairment…Electrophysiological Tremor Analysis In Tremor-Dominant And Postural Instability And Gait Difficulty Phenotypes Of Parkinson’s Disease
Objective: To define the differences in characteristics on electrophysiological tremor analysis between the tremor-dominant (TD) and Postural Instability and Gait Difficulty (PIGD) phenotype. Background: Based…Global Parkinson´s Symptoms Index Correlates with Changes in Quality of Life and Autonomy for Activities of Daily Living
Objective: The aim of the present study was to know if a global assessment of Parkinson's disease (PD) using a new proposed index correlated with…Mechanical Ventilation Modifies the Natural History of DCTN1 p.G71A Perry Disease: A 20-Year Longitudinal Study
Objective: To determine whether mechanical ventilation modifies survival and disease trajectory in an expanded Japanese pedigree with DCTN1 p.G71A–related Perry disease. Background: Perry disease is…
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