Longitudinal cognitive trajectories and predictors of dementia conversion in Parkinson’s disease
Objective: To determine clinical predictors of longitudinal cognitive decline and dementia conversion in a real-world Parkinson’s disease (PD) cohort. Background: Cognitive impairment is one of…Effects of Botulinum Toxin Therapy on Depression, Anxiety, Pain, and Quality of Life in Patients with Dystonia
Objective: To evaluate changes in depression,anxiety,pain, and quality of life alongside motor improvement in patients with dystonia treated with botulinum toxin(BoNT). Background: Dystonia is a…Effects of Dance for Parkinson’s on Disease Severity, Functional Mobility, and Habitual Physical Activity: A Feasibility Study
Objective: To examine the feasibility and effects of a Dance for Parkinson’s Disease® (DfPD®) intervention on disease severity, functional mobility, fine manual dexterity, and habitual…Real-World Clinical Outcomes of Adaptive versus Continuous Deep Brain Stimulation in Early-Stage Parkinson’s Disease: A Systematic Review and Meta-Analysis of 2024-2025 Trials
Objective: To evaluate the comparative efficacy, safety, and energy efficiency of adaptive deep brain stimulation (aDBS) versus continuous deep brain stimulation (cDBS) in Parkinson’s disease…Intravenous AAVrh.10hFXN (LX2006) Gene Therapy in Friedreich Ataxia: Early Neurologic Assessment from Two Phase 1 and 2 Studies
Objective: To evaluate neurologic measures of efficacy of intravenous AAVrh.10hFXN (LX2006) gene therapy in adults with Friedreich ataxia, based on data from the SUNRISE-FA study…Emergence of Cortical Amyloid from the Prodromal Stage of the Lewy Body Disease Spectrum: Evidence from a PiB-PET Study
Objective: To characterize β-amyloid (Aβ) deposition across the Lewy body disease (LBD) spectrum using Pittsburgh compound B positron emission tomography (PiB-PET) and examine the influence…Icariin, a Flavonoid from Epimedium, Confers Dopaminergic Neuroprotection and Neuromodulation in MPTP-Induced Parkinsonian Rats
Objective: The present study aims to evaluate the neuroprotective and neuromodulatory properties of icariin in an MPTP-induced Parkinsonian rat model. Background: Parkinson Disease (PD) is…Characterising Consent and Engagement with Remote Blood Collection in PREDICT-PD
Objective: To characterise patterns of non-consent to optional biosample donation (Aim 1) and post-consent engagement (Aim 2) with remote blood collection in PREDICT-PD. Background: PREDICT-PD…Cross-Family Analysis of Rare Deleterious Variants Segregating in Families with Parkinson’s Disease
Objective: To identify potential novel variants and genes associated with Parkinson’s disease (PD) in multiplex families. Background: Identifying novel genes associated with PD is critical…Online Assessments Measure Motor and Cognitive Progression in People with and without Parkinson’s Disease
Objective: To evaluate longitudinal progression in online participant reported outcomes (PROs) among people with Parkinson’s disease (PD), prodromal PD, and healthy controls. Background: Collecting PROs…
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