SIRT3 upregulation in nigral dopaminergic neurons preserves motor circuit integrity for anti-sarcopenia
Objective: To determine whether enhancing resilience of substantia nigra dopaminergic neurons preserves motor circuit integrity. Background: Degeneration and dysfunction of substantia nigra pars compacta (SNpc)…Distinct Non-Motor Symptom Progression Subtypes in Parkinson’s Disease Identified Using a Data-Driven SuStaIn Model
Objective: To identify progression-oriented non-motor symptom subtypes in PD using a probabilistic Subtype and Stage Inference (SuStaIn) model applied to routinely available clinical assessments. Background:…Strategies for Harmonising Clinical Data for Multi-Centre, Large Scale Genome-Wide Association Studies
Objective: To establish a data harmonisation framework for classifying cognitive status in Parkinson’s disease (PD) across multiple study and data types to facilitate large-scale genetic…Association Between Esophageal Motility and Gait in Parkinson’s Disease: Possible Differential Mechanisms by Esophageal Region
Objective: To investigate the association between esophageal motility and quantitative gait parameters in patients with Parkinson's disease (PD). Background: PD is the second most common…Parkinson’s Disease Early Diagnostic and Prognostic Biomarkers Identified by Large-scale Plasma and Cerebrospinal Fluid Proteomic Profiling
Objective: To identify reliable diagnostic and prognostic protein biomarkers for early-stage Parkinson’s disease (PD) using large-scale proteomic profiling of plasma and cerebrospinal fluid (CSF).To identify…Remote Longitudinal Follow-up of Participants in the Parkinson’s Progression Markers Initiative (PPMI)
Objective: To assess a personalized protocol focused on maintaining contact for long-term follow-up of current and former clinical research participants Background: PPMI-FOUND enrolls participants at…The Impact of the Edmond J. Safra Nurse Educator Program at the Parkinson’s Foundation on Nursing Education and Parkinson’s Care
Objective: To explore the influence of the Edmond J. Safra Nurse Educator Program on nursing education and its impact on preparing future nurses to care for…Cerebellar cholinergic denervation relates to impaired gait and cerebellocortical resting-state functional connectivity in Parkinson disease
Objective: The purpose of this cross-sectional study was to investigate the cholinergic denervation of the cerebellum and its contribution to impaired gait and cerebellocortical resting-state…Stimulation-Level Sweet-Spot and Connectivity Analysis of Pallidal DBS in Huntington’s Disease
Objective: To assess clinical outcomes and identify stimulation and structural connectivity patterns associated with motor improvement in Huntington’s Disease (HD) patients undergoing DBS. Background: DBS…Late onset chorea secondary to antiphospholipid syndrome with radiological correlation on brain FDG-PET: a case report.
Objective: To describe chorea as the initial manifestation of antiphospholipid syndrome (APS) and its radiological correlation on brain FDG-PET as an autoimmune movement disorder. Background:…
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