Temporally Patterned Deep Brain Stimulation Improves Gait Metrics and Freezing of Gait in Parkinson’s Disease
Objective: To investigate the clinical impact of temporally patterned deep brain stimulation (DBS) on gait and Freezing of Gait (FoG) in Parkinson’s disease (PD). Background:…Longitudinal gait changes after unilateral and bilateral MRgFUS thalamotomy in Essential Tremor
Objective: To evaluate changes in gait parameters Essential Tremor (ET) patients treated with unilateral or bilateral Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy, and to assess…Cerebellar cholinergic denervation relates to impaired gait and cerebellocortical resting-state functional connectivity in Parkinson disease
Objective: The purpose of this cross-sectional study was to investigate the cholinergic denervation of the cerebellum and its contribution to impaired gait and cerebellocortical resting-state…Impact of Alpha-Synuclein Burden and Cellular Stress on GBA-PD Macrophage
Objective: This study explores how non-neuronal dysfunction drives the rapid progression of GBA-PD, aiming to identify therapeutic targets that restore protein degradation and cellular stability.…Platelet Lipididomic and Alpha-Synuclein as Peripheral Biomarkers of Disease Progression and Risk in GBA1-Associated Parkinson’s Disease
Objective: To evaluate whether integrated platelet lipidomic and α-synuclein signatures can distinguish idiopathic Parkinson’s disease (iPD), GBA1-associated PD (GBA-PD), and GBA1 non-manifesting carriers (GBA-NMC) from…Parkinson’s Disease and Parkinsonism Family Center Psychoeducational Program for Patients and Caregivers
Objective: To provide structured psychoeducational and informational support, including disease education, coping and self-management strategies, and guidance on healthcare and social services for Parkinson’s disease…Developing non-invasive EEG biomarkers for Parkinson’s disease using concurrent subthalamic nucleus/cortical recording as ground truth.
Objective: In the present study, we aimed to: (1) isolate the motor cortical EEG activity responsible for translating subthalamic nucleus (STN) beta hypersynchrony into bradykinesia;…The influence of probable rapid eye movement sleep behavior disorder on PD-related motor and non-motor symptoms and multiple functional outcomes among Chinese community-dwelling elderly population
Objective: To investigate associations of probable REM sleep behavior disorder (pRBD) with Parkinson's disease (PD)-related symptoms and functional outcomes in Chinese older adults. Background: The…Neurofilament Light Chain Triggers Protein Aggregation, Neurotoxicity and Gliosis in Parkinson’s Disease through p38/MK2/NF-κB/CREB1 and Nrf2/HO-1 Signalling
Objective: This research investigated the active pathogenic property of Neurofilament light chain (NfL) in contributing to PD-like pathophysiology. We aimed to elucidate these mechanisms by…Postural Sway Frequencies in Isolated REM Sleep Behavior Disorder Might Indicate Subtle Motor Impairments as Prodromal Marker of Parkinson’s Disease
Objective: In this preliminary study, we aimed to compare postural sway between individuals with early, untreated Parkinson’s disease (PD), individuals with isolated REM sleep behavior…
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