A prospective study of Parkinson’s disease progression towards dementia – dynamics and defining motor features
Objective: Our goal was to investigate the rate of progression to dementia (PDD) in our cohort of Parkinson’s disease (PD) patients and to explore how…Parkinson’s Disease, Cognitive Function and Medication Management: A Problem in Routine Care
Objective: Explore the relationship between objective and patient-reported assessment of cognition to patient-reported medication management capabilities. Background: Parkinson’s disease (PD) is a complex neurodegenerative disorder…Statistical methods for dealing with missing data in longitudinal studies with application to Parkinson’s disease cognition research
Objective: To assess the performance of standard techniques for handling missing data in longitudinal studies under a variety of missing data scenarios. We demonstrate our…Identification of a new Homozygous mutation P.R258Q In the gene SYNJ1 of an Algerian consanguine (inbred) Family suffering from early onset atypical Parkinsonism
Objective: The purpose of this observation is to demonstrate that autosomal recessive early parkinsonism is clinically and genetically heterogeneous Background: Early Onset Parkinson’s disease is…The Global Parkinson’s Genetics Program (GP2) – a year’s progress
Objective: The Global Parkinson’s Genetics Program (GP2, http://gp2.org/) aims to dramatically expand the current understanding of the genetic architecture of Parkinson’s disease (PD) and to…The application of Next Generation Sequencing in the Parkinson Disease.
Objective: This study aims to better investigating the pathogenetic of PD and improving the diagnostic approach in the molecular genetics, using the NGS. Background: Parkinson’s…Interrogating Parkinson’s disease associated mutations at single cell resolution
Objective: To uncover potentially causative Parkinson’s disease (PD) somatic mutations in post-mortem substantia nigra pars compacta (SNpc) tissues from sporadic PD patients using single cell…The Commercial Genetic Testing Landscape for Parkinson’s Disease
Objective: To evaluate commercial genetic testing offered for Parkinson’s disease (PD) Background: The etiology of PD is complex and, typically, multifactorial. At least 6 genes…GP2: training the next generation of Parkinson’s disease genetics researchers – wherever they are in the world
Objective: To establish a virtual ‘center of excellence’ with resources and expertise to serve the training needs of the Global Parkinson’s Genetics Program (GP2; www.gp2.org)…A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson’s disease
Objective: To report the identification of a novel variant in the gene encoding alpha-synuclein (SNCA), segregating with Parkinson’s Disease (PD) in two families of Turkish…
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