WATCH-PD: Detecting Early-Stage PD using Feature Engineering and Machine Learning in Remote Sensor-Based Assessments
Objective: Use feature engineering and machine learning to evaluate digital biomarkers of early-stage Parkinson’s disease (PD) in the WATCH-PD study. Background: WATCH-PD – a one-year…Detecting Parkinson’s Disease from body limb acceleration using machine learning and a frequency-domain analysis
Objective: To test whether the acceleration frequency of different body parts during gait can reveal characteristic patterns of Parkinson’s Disease (PD). The technical aim was…Amygdala-hippocampus damage critically contributes to visual dysfunction in Parkinson disease
Objective: To delineate the structural and functional alterations of the brain associated with visual dysfunction and retinal injury in Parkinson disease (PD) Background: Several electrophysiological,…Characterization of neuromelanin MRI as a potential Parkinson’s Disease biomarker in a multi-site longitudinal study
Objective: To investigate (1)longitudinal change and (2)cross-sectional vendor differences in neuromelanin MRI in substantia nigra pars compacta(SNpc) in PD patients. Background: Neuromelanin(NM) MRI is a…Neuroanatomical underpinnings of apathy in Parkinson’s Disease
Objective: To investigated the integrity of white matter tracts within basal ganglia-frontal networks in PD patients with and without apathy, and relate these to specific…A Narrative Review of Literature on Exercise Therapy and Cognitive Impairment in Individuals with Parkinson’s Disease: The Role of Epigenetics as a Mediator.
Objective: This narrative review explored the potential role of exercise as an epigenetic mediator of cognitive function in people with PD and the possible underlying…Trends in incidence of hospitalizations in Parkinson´s Disease in Spain (2010-2019)
Objective: To estimate the incidence of in-hospital admissions of Parkinson´s disease (PD) in Spain during the last decade (2010-2019) and describe the epidemiology of these…Inflammatory changes in subjects with de novo Parkinson’s disease
Objective: To examine whether inflammation is present in subjects newly diagnosed with Parkinson’s disease (PD). Background: Evidence for the role of inflammation in PD has…IncobotulinumtoxinA to treat sialorrhea in Parkinson’s disease: a real-life study
Objective: We evaluate the long-term efficacy and safety of incobotulinumtoxinA injections in advanced Parkinson’s disease (PD) patients suffering from sialorrhea (10 injection cycles (IC) into…Safety and tolerability of Nilotinib in patients with Huntington’s disease
Objective: To investigate the safety and tolerability of nilotinib, an FDA-approved drug for leukemia, in individuals with Huntington’s disease (HD). Background: Previous clinical studies in…
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