The mGlu2 positive allosteric modulator BINA extends enhances low dose L-DOPA anti-parkinsonian action in the MPTP-lesioned marmoset
Objective: To determine the effect of positive allosteric modulation of the metabotropic glutamate type 2 (mGlu2) receptor in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned marmoset using a low…A user experience evaluation of a Huntington’s disease app: Implications for mobile-first design
Objective: To evaluate usability, functionality, and interface design to inform improvements for future iterations of the GEORGE® app for use in research. Background: GEORGE® is…What is the appropriate sleep position for Parkinson’s disease patients with orthostatic hypotension in the morning?
Objective: To determine the effect of sleep positions on morning OH in PD patients Background: Orthostatic hypotension (OH) is considered one of the most disabling…A Single-Centre Canadian Study of Disparities in Access to Deep Brain Stimulation for Movement Disorders
Objective: To identify disparities in gender and ethnicity among deep brain stimulation (DBS) patients to reduce differences in access to care by implementing strategies to…Use of virtual reality devices for the monitoring of Parkinson’s disease
Objective: To determine whether mass market virtual reality (VR) devices can be used to detect the motor manifestations of Parkinson’s disease and their response to…Comorbid neuropathological features in multiple system atrophy
Objective: To elucidate the distribution of comorbid neuropathology in multiple system atrophy (MSA) and its clinical correlation. Background: Multiple protein accumulations are often present in…A Scoping Review of Multidisciplinary Care in Tourette Syndrome
Objective: To review current multidisciplinary care practices in patients with Tourette syndrome (TS). Background: Individuals with TS can have multiple symptoms and co-morbidities and require…Parkinson’s disease and nucleus basalis of Meynert integrity: Cognition and everyday function
Objective: To examine the association between the integrity of the nucleus basalis of Meynert (NBM), cognition and everyday function in Parkinson’s disease (PD). Background: Most…Perceptions of Palliative Care in Huntington’s Disease
Objective: This study aims to identify perceptions of palliative care in Huntington’s Disease (HD), palliative care needs of patients with HD, and at what point…Movement Disorders in Hereditary Spastic Paraplegia (HSP): A Systematic Review and Individual Participant Data Meta-Analysis
Objective: To investigate genotype-phenotype associations in hereditary spastic paraplegia (HSP) with a focus on movement disorders. Background: HSP is a rare genetically-driven disorder associated with…
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