Subthalamic tremor-related oscillatory neurons play a role in the generation of Parkinson’s tremor
Objective: To explore whether subthalamic tremor-related oscillatory neurons is involved in the generation of Parkinson’s tremor. Background: Both the basal ganglia and cerebello-thalamo-cortical circuits appear…Nicotine and influences on hyperkinetic movement disorders
Objective: We describe hyperkinetic movement disorders with a variable response to smoking and nicotine and review clinical and pre-clinical evidence regarding the role of smoking,…A brainstem-oriented PET/NMR method in Parkinson’s disease
Objective: To create a voxel-based method, oriented to the brainstem and allowing the detection of Parkinson’s disease (PD) and the study of the altered connectivity…Beyond the subthalamic nucleus: tractography patterns of Magnetic Resonance-guided Focused Ultrasound subthalamotomy
Objective: To identify subthalamic clusters that predict maximum improvement in bradykinesia, rigidity and tremor. To map-out the cortical fingerprint, which predict maximum efficacy. Background: Subthalamotomy…Automated scoring of REM sleep without atonia using the open-source software RBDtector
Objective: To facilitate quantification of REM sleep without atonia (RSWA) and thereby identify patients with rapid eye movement (REM) sleep behaviour disorder (RBD). Background: RBD…Neurovascular and immune determinants of selective vulnerability of dopaminergic neurons in Parkinson’s Disease
Objective: We aimed to investigate the contribution of glial cells activation and immune cells infiltration in the selective vulnerability of dopaminergic neurons within the midbrain…Focused Ultrasound Subthalamotomy in Parkinson’s Disease: Lesion Topography and Motor Improvement.
Objective: To describe the topography of unilateral focused ultrasound (FUS) subthalamotomy in Parkinson’s disease (PD), and define correlations between lesion size/location and improvement of cardinal…Improving the design of clinical trials in early-stage Parkinson’s disease by using the estimand framework
Objective: To show how the estimand framework can be used to improve design of clinical trials testing treatments in early-stage Parkinson’s disease (PD). Background: The…Characterization of gastrointestinal dysfunction in Parkinson’s by disease stage
Objective: To conduct a comprehensive cross-sectional and longitudinal characterization of gastrointestinal dysfunction (GID) in Parkinson’s disease (PD). Background: GID is an important feature of PD…Medication safety in Parkinson’s disease patients: evaluation of recommendations for decision support in the national drug-disease interaction database
Objective: Objective: Drug-disease interactions in Parkinson's disease patients can give rise to situations where a drug may have negative effects on both motor- and non-motor…
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