The potential role of Per- and Polyfluoroalkyl Substances (PFAS) in movement disorders: Implications and Risk assessment to Human Health
Objective: The objective of our study is to critically summarized the neurotoxicity of Perfluoroalkyl substances (PFAS) and linked this environmental pollutant with movement disorders and…Genetic determinants of early motor progression in Parkinson’s cohorts
Objective: To determine the genetic determinants of motor progression in Parkinson disease (PD) using genome-wide analysis correlated with the MDS-UPDRS Part III motor scale. Background:…Non-apoptotic caspase-3 activation mediates early synaptic dysfunction of indirect pathway neurons in the parkinsonian striatum
Objective: We set out to investigate whether caspase-3 plays a role in the loss of dendritic spines and the concomitant synaptic deficits that develop in…Pallidal Deep Brain Stimulation for Treatment of Poststroke Hemichorea
Objective: We report a case of medication-refractory poststroke hemichorea where deep brain stimulation of the globus pallidus internus (GPi-DBS) was utilized to alleviate hemichorea. Background:…The distinctive functional connectivity of the cholinergic nucleus basalis of Meynert in Parkinson’s disease across different motor subtypes
Objective: We aim to compare the state of cortical-NBM functional connectivity across healthy control (HC), PIGD-predominant PD (PIGD-PD), and tremor-dominant PD (TD-PD). Additionally, the correlation…Biochemical markers of glucocerebrosidase (GCase) deficiency in primary macrophages derived from GBA1 mutation carriers with and without Parkinson’s disease
Objective: The aim of the present study was to assess biochemical markers in primary macrophages that could distinguish patient with Parkinson’s disease linked to mutations…Blood Lipid Biomarkers in Early Parkinson Disease and Parkinson Disease with Mild Cognitive Impairment
Objective: This study aims to investigate the association between comprehensive blood lipid biomarkers and Parkinson's disease (PD). Background: Studies have shown that the serum levels…The Hidden Disease Burden and Treatment Experience of Patients with Essential Tremor: A Retrospective US Claims Analysis
Objective: To describe the attributes of patients with essential tremor (ET), associated comorbidities, and ET treatments using a US claims database. Background: ET is estimated…Covid vaccine induced parkinsonism and cognitive dysfunction
Objective: To describe movement disorder and cognitive impairment in two patients following COVID-19 vaccination. Background: The manifestation of neurological complications have been increasingly evidenced following…A novel alpha-synuclein gene (SNCA) missense variant in an Austrian familiy with atypical neuropathological features
Objective: To offer clinical, genetic and neuropathological information in a novel alpha-synuclein gene (SNCA) missense variant to further our understanding of synucleinopathies. Background: Around 5–10% of…
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