Early Synucleinopathy is Associated with Differential Regulation of Neurotransmission and Immune Related Genes
Objective: Identification of gene expression changes in the rat substantia nigra pars compacta (SNpc) associated with early alpha-synuclein (a-syn) inclusion formation. Background: Accumulation of intracellular…Long-term non-motor and motor outcome after subthalamic stimulation in Parkinson’s disease
Objective: The primary objective of this study was to document the evolution of independence in activities of daily living in people with Parkinson’s disease treated…Changes in gait and mobility measures collected in daily living conditions, in different stages of Parkinson’s disease
Objective: To explore mobility measures collected in daily-living conditions in different stages of PD. Background: Gait and mobility impairments are considered a cardinal sign in…Anatomical Substrates for Motor Subcomponents of Bradykinesia in Parkinson’s Disease after Subthalamic Nucleus Deep Brain Simulation
Objective: To evaluate distinct anatomical substrates modulating motor subcomponents of bradykinesia following Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS) in Parkinson’s Disease (PD). Background: PD…The anti-alpha-synuclein antibody Lu AF82422 binds to pathological alpha-synuclein species from human brains and inhibits seeded alpha-synuclein aggregation
Objective: Lu AF82422 is a human IgG1 monoclonal antibody that binds all known forms of alpha-synuclein (aSyn), including monomeric, aggregated and truncated. Data are presented…The 20-item Noise Pareidolia Task is uniquely sensitive to Visual Hallucinations in Parkinson’s Disease
Objective: The purpose of this study was to examine clinical utility of the 20-item Noise Pareidolia Task (NPT20) in Parkinson’s disease (PD), as indicated by…Alteration of lysosomal enzymatic activities in blood of patients with schizophrenia
Objective: To estimate whether alteration of lysosomal activities contributes to schizophrenia (SCZ) pathogenesis, age at onset and risk of developing the disease. Background: SCZ is…Deep Brain Stimulation in Woodhouse Sakati Syndrome:A Single Institution Retrospect Analysis
Objective: Evaluation of clinical response in patients with WSS-associated generalized dystonia following DBS to GPI Background: Woodhouse–Sakati syndrome (WSS) is a rare autosomal recessive disease,…Corticobasal syndrome and Parkinson’s disease at the beginning: usefulness of different asymmetrical patterns for early diagnosis.
Objective: To evaluate R2 Blink Reflex Recovery Cycle (R2BRRC) and cortical thickness in drug-naïve PD patients and in CBS patients for characterizing pathophysiological mechanisms underlying…DNMT1 level and global DNA methylation in CD45+ blood cells in Parkinson’s disease
Objective: The aim of our study was to assess the alterations in DNA methyltransferase1 (DNMT1) level and global DNA methylation (5-mC) in CD45+ blood cells…
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