Objective: Correlation of non-motor symptoms such as pain, anxiety, and depression in the quality of life and severity of the disease in patients living with Parkinson Disease in our population

Background: Parkinson’s disease (PD) is a neuropsychiatric disease that affect 10 million people. There are non-motor symptoms such as pain, anxiety and depression that directly affect the patient’s quality of life, these symptoms usually precede classical manifestations by up to 10 years.

Method: Descriptive cross-sectional study, Consecutive patients were enrolled patients from the anormal movements clinic in our hospital. Sociodemographic and clinical data were collected.  The quality of life of patients with Parkinson disease was assessed by Parkinson’s Disease Questionnaire (PDQ-8) and the EuroQol-5D (EQ-5D). the presence of pain and moods disorders assessed according

to the Unified Parkinson’s Disease Rating Scale, part I (UPDRS-I). For the statistical analysis, chi square was used forma UPDRS-I variables with disease stage by H&Y, also compare means using quality life variables (PDQ-8 and EQ5) with presence of pain or mood disorders

Results: A total of 104 patients with PD diagnosis were enrolled, 68.3% male, the initial side of the disease was right-handed in 61.2%, tremor was the most frequent initial symptom with 59.8% followed by rigidity in 33.3%. 43.3% presented a H&Y stage 2; EQ5 score median 70 points (50-85); UPDRS 62 (39-98); H&Y disease stage correlation with pain (p<0.001), anxiety (p=0.030), and depression (p=0.010) EQ5 with pain (p=0.016) and depression (p= 0.025) PDQ8 with anxiety (p=0.001) and depression (p<0.001)

Conclusion: The presence of pain in PD is recognized in the literature in up to 40-85%, in our study 52.9% were evidenced with complaints of pain through MDS-UPDRS, as reported in the literature there is a significant correlation with the presence of pain and mood disorders in patients with more advanced stages of the disease on the H&Y scale, as well as presenting mood disorders correlated with greater presence of pain

Pain and mood disorders in Parkinson’s have not been well established. They can appear at any time during the disease, consistent with initial damage to the limbic system prior to motor circuits, frequent non-motor symptoms, and affecting quality of life in patients with PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/pain-and-moods-disorders-as-determinants-of-quality-of-life-in-parkinson/