Session Information
Date: Monday, June 20, 2016
Session Title: Parkinson's disease: Non-motor symptoms
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: This study aimed to 1) examine the clinical characteristics of pain in patients with Parkinson’s disease(PD) and 2) explore the correlation between pain and sleep disturbance in PD patients.
Background: Both sleep disorders and pain in PD severely influence patient’s quality of life.To date, little is known about the particular association between objective sleep disturbances and pain in PD population.Knowledge of correlation between pain and abnormalities in the sleep process might direct the development of novel intervention strategies.
Methods: 144 PD patients with or without pain were enrolled in the study and all underwent extensive clinical evaluations including motor and non-motor symptoms of PD, clinical features of pain were particularly documented. An overnight video-polysomnography (PSG) was also conducted. Clinical manifestations and PSG parameters were compared in PD patients with(PD+pain) or without(PD-pain) pain. According to their pain types, PD+pain patients were then divided into two subgroups: musculoskeletal pain(MSP) and miscellaneous pain (MLP), and further comparisons were performed between the two subgroups.
Results: Pain was reported by 75 (52.1%) participants, with 49 (65.3%) reporting pain of moderate severity or worse. PD+pain group had older age, longer disease duration, higher H/Y stage, higher scores for UPDRS, HRSD, PDQ-39, NMSQ, PSQI, ESS and more L-dopa equivalent daily dose compared to PD-pain group (all p < 0.05). Exacerbation of altered sleep continuity and sleep architecture was also found in PD+pain group. No significant differences were found between PD+pain subgroups for motor, non-motor symptoms or sleep parameters. Binary logistic regression analysis revealed that depressed mood, higher NREM stage 1% and lower sleep efficiency were independent correlates of pain in PD patients.
Conclusions: Musculoskeletal pain is the most common type of pain in Parkinson’s disease. Disrupted sleep continuity, altered sleep architecture and depressed mood may be associated with pain in PD patients.
To cite this abstract in AMA style:
Y. Fu, C. Mao, L. Ma, M. Ding, Y. Wang, C. Liu. Pain correlates with sleep disturbances in Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/pain-correlates-with-sleep-disturbances-in-parkinsons-disease/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/pain-correlates-with-sleep-disturbances-in-parkinsons-disease/