Date: Thursday, June 8, 2017
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: To evaluate patient and caregiver usability and satisfaction with the mini-pump that will be used for continuous ND0612 delivery among patients with moderate-severe PD.
Background: ND0612 is an investigational drug-device combination utilizing the first and only liquid formulation of levodopa/carbidopa (LD/CD) administered continuously subcutaneously by a mini-pump. In clinical studies to date, ND0612 was shown to achieve constant levels of LD in the blood and improvement in disease symptoms such as OFF time.
Methods: In this human factor study, 15 PD patients, along with their partner were invited to partake in 4 sessions of 90 minutes during which they were trained on how to set up and operate the pump system. Participants also simulated the infusion to a dummy skin pad. For the training process, training aids such as step-by-step live demonstration and use of a pictorial patient guide were used as well as a quick link for a 24/7 helpline. Outcomes evaluated were the ability to assemble and operate the pump independently or with the help of a caregiver and to comprehend and appropriately respond to potential use errors.
Results: All of the 15 pairs that participated in the study were able to assemble and operate the mini-pump following training, demonstrating user-learning ability and overall satisfaction with use of the device. Despite inherent motor difficulties, patients were able to perform the tasks requiring fine motor skills such as drug loading and connection of infusion line. The pictorial training materials effectively aided PD patients in achieving safe operation of the pump.
Conclusions: The ND0612-associated mini-pump was well perceived by PD patients and their caregivers, following appropriate and effective training and the use of training aids. Delivery of ND0612 via a subcutaneous mini-pump offers a novel, easy-to-use, patient-controlled system to achieve constant levels of LD in the blood that today can be achieved only after surgical intervention.
To cite this abstract in AMA style:S. Nash, M. Gera, E. Shor, T. Rachmilewitz Minei, S. Oren. Patient perspectives of using the ND0612 mini-pump [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/patient-perspectives-of-using-the-nd0612-mini-pump/. Accessed March 5, 2024.
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