Session Information
Date: Wednesday, September 25, 2019
Session Title: Neuroimaging
Session Time: 1:15pm-2:45pm
Location: Les Muses Terrace, Level 3
Objective: To study changes in subsystems in drug-naïve Parkinson’s disease with mild cognitive impairments using resting-state functional connectivity MRI.
Background: Mild cognitive impairment (MCI) is common in Parkinson’s disease (PD), and is associated with disrupted connectivity in networks relevant to cognition, most prominently the default mode network (DMN). The DMN comprises at least three subsystems: the core (the anterior medial prefrontal cortex (aMPFC) and posterior cingulate cortex (PCC)), and the dorsal MPFC (DMPFC) and medial temporal lobe (MTL) subsystems. However, little is known regarding changes in these subsystems in PD.
Method: We calculated the strength of functional connectivity (FC) in the DMN intra- and inter-subsystems and the regional FC strength (FCS). The FCS was compared between any two groups from 28 drug-naïve PD patients with MCI (PD-MCI), 19 drug-naïve PD patients with cognitive unimpaired (PD-CU), and 28 age-, sex-matched healthy controls (HCs) by using the nonparametric permutation method (10 000 permutations) with age, sex and education as covariates.
Results: For intra-subsystems, the decreased FCS occurred in the DMPFC subsystem of PD-MCI patients but not in the MTL subsystem or core compared with HCs. For inter-subsystems, PD-MCI patients showed decreased FCS between the PCC and DMPFC subsystem compared with HCs (p<0.01, uncorrected). Furthermore, the temporal parietal junction (TPJ) in the DMPFC subsystem showed decreased regional FCS in the PD-MCI subgroup relative to the HC group (p<0.05, FDR corrected). No significant change of FCS was found between PD-MCI and PD-CU patients, and between PD-CU patients and HCs.
Conclusion: Decreased intrinsic FC was mainly associated with the DMPFC subsystem in the PD-MCI subgroup, suggesting that the DMPFC subsystem is predominantly disrupted.
To cite this abstract in AMA style:
YB. Hou, QQ. Wei, RW. Ou, J. Yang, W. Song, QY. Gong, HF. Shang. Primary disruption of the subsystems of the default mode network in drug-naïve Parkinson’s disease with mild cognitive impairments: a resting-state functional connectivity MRI study [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/primary-disruption-of-the-subsystems-of-the-default-mode-network-in-drug-naive-parkinsons-disease-with-mild-cognitive-impairments-a-resting-state-functional-connectivity-mri-study/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/primary-disruption-of-the-subsystems-of-the-default-mode-network-in-drug-naive-parkinsons-disease-with-mild-cognitive-impairments-a-resting-state-functional-connectivity-mri-study/