Date: Monday, June 5, 2017
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: To evaluate the extent of degeneration in dopamine nerve terminal in striatum in the patients with MSA-P and MSA-C, and to compare the progression speed of the degeneration to the patients with Parkinson’s disease, Dat-SPECT imaging was carried out.
Background: MSA, involving neurons both in substantia nigra and striatum, is resulted in reduction of dopamine nerve terminals in striatum. DaT-SPECT employing 123I-Ioflupane, accumulating in dopamine nerve terminal, has enabled to visualize and evaluate the severity of degeneration of nigro-striatal dopamine system. Previously we reported the profound reduction of the DAT-SPECT signal in the patients with MSA especially with MSA-P.
Methods: 21 patients with MSA; 5 with MSA-P and 16 with MSA-C, 47 patients with Parkinson’s disease are analyzed in this study. Accumulation of 123I-Ioflupane in striatum was visualized, calculated and evaluated with a software QSPECT with specific binding ratio (SBR) in each subject. Progression index ( (SBR in QSPECT-4.5) /disease duration) in each group was calculated and compared by t-test.
Results: To evaluate the patients with Parkinson’s disease, regression line between disease duration and SBR in occipital background reference is obtained. Two regression line of Parkinson’s disease and MSA-C gave a similar intercept point on y-axis (ie. starting point of diseases) around 4.5. Using this results, we estimated progression speed by the formula: PI=(SBR QSPECT-4.5)*100/disease duration(y). Statistically positive difference in progression index (PI) between MSA-P and MSA-C, also between MSA-P and Parkinson’s disease was obtained. There was no difference between MSA-C and Parkinson’s disease.
Conclusions: These results suggests faster progression of the disease process of basal ganglia in MSA-P than in MSA-C and Parkinson’s disease.
To cite this abstract in AMA style:I. Toyoshima, T. Hatakeyama, E. Abe, C. Wada, M. Kobayashi, K. Obara. Profound reduction of DAT-SPECT signal in multiple system atrophy (MSA) [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/profound-reduction-of-dat-spect-signal-in-multiple-system-atrophy-msa/. Accessed December 11, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/profound-reduction-of-dat-spect-signal-in-multiple-system-atrophy-msa/