Objective: In the Indian agricultural health study cohort, we evaluated the relationship between prospective exposures to organic fungicides and herbicides and the incidence of Parkinson’s disease, generally and by histological subgroup, followed over 4 years in Kanpur district, northern India.

Background: Agriculture pesticides exposures could be implicated in the excess of Parkinson’s disease (PD) experiential in Indian farmers, however, with few exceptions, little is known about associations between specific pesticides and PD.

Method: We evaluated use of pesticides and incident PD in 10,542 pesticide applicators in the agricultural health study cohort, implicated in agriculture. Incident Parkinsonism were recognized by linkage with PD registries from enrolment (2019-2022) until December 2022. We used self-reported information on specific exposures were assessed by combining information on time duration periods of insect killer use on crops and the Indian crop-revelation medium synergists, for each of the 23 specific organic and thiocarbamate herbicides and the 28 carbamate and Mothballs fungicides registered in India. We estimated covariate-adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression.

Results: For the period of an average proceedings of 4 years, 908 confrontation cases of Parkinsonism occurred, include 806 multiple system atrophy and 203 vascular Parkinsonism self-reported incident doctor-diagnosed PD. Analyses showed improved risks of Parkinsonism with overall exposure to organic fungicides (Hazard Ratio, HR = 2.67; 94% CI: 2.21-3.43) and, to a slighter extent, to organic herbicides (HR = 2.24; 67% CI: 0.97-2.82). optimistic relations were observed with specific organic, including some fungicides (Copper, maneb, jojoba, metiram) and herbicides (diallate propham and chlorpropham, ,) already suspected of being carcinogens in animal and plants. We observed PD heterogeneity in applicators, with higher risk among those who reported a history of head injury, or who did not use gloves.

Conclusion: Present study concludes of increased PD risk for some pesticides.  Although some additional studies should be interpreted carefully, these findings provide supplementary mechanisms relevant to PD facts for several carbamate herbicides and fungicides.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/relationship-between-agricultural-vulnerability-to-organic-compound-fungicides-and-herbicides-and-parkinsons-disease-incidence-in-rural-population-in-northern-india/