Objective: To clarify the characteristics of decreased physical activity and relationship between physical activity intensity and Insulin-like Growth Factor-1 (IGF-1) in patients with Parkinson’s disease (PD).　

Background: IGF-1 is a neuro-protect substance and may prevent cognitive decline. Muscle activity is known to accelerate secretion of IGF-1; however, little has been known about the role of IGF-1 in PD patients.

Methods: This study included 35 PD patients (Hoehn & Yahr: 1 to 4) who visited Fukuoka University Hospital from July 2015 to October 2015. The amount of physical activity was calculated by using a 3-axis accelerometer, and an average of daily Moderate-to-Vigorous Physical Activity (MVPA) and Low Physical Activity (LPA) was calculated. Blood sample was collected for measurement of serum IGF-1. The physical activity intensity was compared with the control group (n=70), and then the correlation analysis of the physical activity intensity and the serum IGF-1 was carried out.

Results: Compared with the control group, both MVPA (p<0.001) and LPA (p<0.001) were lower in PD patients. In PD patients, there was correlation between IGF-1 and MVPA (over 3.5METs) (Spearman’s rank correlation coefficient：p=0.033). however, no correlation was seen with LPA．

Conclusions: Lower physical activity intensity might be caused by slowness of movement and inactive living patterns of PD patients. Lower MVPA seems to be correlated with lower serum IGF-1, indicating that exercise for higher activity intensity inducing higher IGF-1 may slow the disease progression due to its neuroprotective effect in PD patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/relationship-between-insulin-like-growth-factor-1-and-characteristics-of-physical-activity-in-patients-with-parkinsons-disease/