Session Information
Date: Wednesday, September 25, 2019
Session Title: Non-Motor Symptoms
Session Time: 1:15pm-2:45pm
Location: Agora 3 West, Level 3
Objective: We aimed to assess the association among RBD, olfactory function and clinical symptoms in patients with Parkinson’s disease (PD).
Background: Rapid eye movement sleep behavior disorder (RBD) and olfactory dysfunction are common clinical non-motor symptoms and useful for early diagnosis in patients with PD. RBD and severe olfactory dysfunction are also regarded as risk factors for cognitive impairment in PD.
Method: Subjects were 417 PD patients without dementia (age 68.1 ± 8.1 years; 192 males, 225 females, mean Mini-Mental Examination score 28.3 ± 2.5 points) with average disease duration of 6.5 years. 84% of subjects were taking anti – PD medication. Levodopa equivalent dose (LED) averaged 477 mg / day. The presence of RBD symptoms was determined using the RBD screening questionnaire Japanese version (RBDSQJ) and RBD 1Q. Olfactory function was evaluated by odor identification test for Japanese consisting of 12 different odorants. Clinical symptoms were evaluated on the Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) part I – IV.
Results: One hundred thirty seven subjects (32.9%) indicated a history of RBD symptoms by RBD 1Q, and 140 subjects (33.6 %) by RBDSQJ when the RBD criterion for RBDSQJ was 6 points or more. The MDS-UPDRS I, II and III scores and the LEDs were significantly higher (p < 0.001), and longer disease duration (p < 0.05) in the group with RBD. RBD was associated with hallucination among MDS- UPDRS part I items, and with male (p < 0.05). The average number of correct answers in the olfactory identification test was 4.4 points in RBD group and 4.9 points in non- RBD group, and there was a declining tendency (p = 0.053) in the RBD group.
Conclusion: There were approximately 30% of subjects with RBD by the questionnaire. Motor and non-motor functions were significantly reduced in PD patients with RBD.
To cite this abstract in AMA style:
M. Iijima, F. Yoshi, K. Suzuki, S. Nogawa, T. Osada, H. Hirata, K. Kitagawa, N. Hattori, Y. Okuma. Relationship between RBD and olfactory disorder, clinical symptoms in Parkinson’s disease [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/relationship-between-rbd-and-olfactory-disorder-clinical-symptoms-in-parkinsons-disease/. Accessed June 15, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/relationship-between-rbd-and-olfactory-disorder-clinical-symptoms-in-parkinsons-disease/