Session Information
Date: Monday, June 20, 2016
Session Title: Epidemiology and Quality of Life
Session Time: 12:30pm-2:00pm
Objective: To evaluate the relationship between the International Parkinson and Movement Disorder Society – Unified Parkinson’s disease Rating Scale (MDS-UPDRS) and Quality of Life (QoL) in a large international, multicenter cohort of patients with Parkinson’s disease (PD).
Background: The MDS-UPDRS is a newly developed comprehensive tool to assess PD, which covers a wider range of disease manifestations including non-motor symptoms (NMS). Its relationship to different aspects of QoL needs further exploration.
Methods: PD patients from countries with a validated language version of the MDS-UPDRS were eligible for inclusion in the study. We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using two hierarchical multiple regressions, controlling for selected covariates. The first regression assessed the relationship between the 4 MDS-UPDRS Part scores and PDQ8. The second regression assessed the relationship between individual items from those Parts demonstrating a significant relationship to the PDQ8 in the first regression.
Results: A total of 3206 PD patients, from the English, Estonian, French, German, Hungarian, Russian, Slovak and Spanish language datasets were included in the study. The mean participant age was 65.8±10.6 years, 53.3% were men, mean disease duration was 11.5±4.6 years and median HY was 2 (range 0-5). In the first regression analysis, after controlling for age, gender and disease duration, PDQ8 was significantly related to MDS-UPDRS Parts I and II, but not Parts III or IV. Therefore, further focus was on individual items from Parts I and II. In the second regression model, after controlling for age, gender, disease duration and motor severity, significant contributions to PDQ8 score were found for Part I items measuring Fatigue, Pain, Depressed mood, Apathy, Features of dopamine dysregulation syndrome; and Part II items measuring Dressing, Doing hobbies, Freezing and Speech. The individual Part I and II items significantly contributing to PDQ8 score varied slightly among the different language cohorts.
Conclusions: This is so far the largest study related to QoL issues in PD. Restrictions in activities of daily living and NMS significantly contribute to QoL in PD, whereas total motor score or complications of therapy (Parts III and IV respectively) does not.
Submitted for 2016 EAN congress in Copenhagen.
To cite this abstract in AMA style:
M. Škorvánek, P. Martinez-Martin, N. Kovacs, I. Zezula, M. Rodriguez-Violante, J.C. Corvol, P. Taba, K. Seppi, O. Levin, A.E. Schrag, T. Foltynie, M. Alvarez-Sanchez, T. Arakaki, Z. Aschermann, I. Aviles-Olmos, E. Benchetrit, C. Benoit, A. Bergareche-Yarza, A. Cervantes-Arriaga, A. Chade, F. Cormier, V. Datieva, D.A. Gallagher, N. Garretto, Z. Gdovinova, O. Gerschanik, M. Grofik, V. Han, J. Huang, L. Kadastik-Eerme, M.M. Kurtis, G. Mangone, J.C. Martinez-Castrillo, A. Mendoza-Rodriguez, M. Minar, H.P. Moore, M. Muldmaa, C. Mueller, B. Pinter, W. Poewe, K. Rallmann, E. Reiter, C. Rodriguez-Blazquez, C. Singer, B.C. Tilley, P. Valkovic, C.G. Goetz, G.T. Stebbins. Relationship between the MDS-UPDRS and quality of life in Parkinson’s disease: A large international multicenter study of 3206 patients (the QUALPD study) [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/relationship-between-the-mds-updrs-and-quality-of-life-in-parkinsons-disease-a-large-international-multicenter-study-of-3206-patients-the-qualpd-study/. Accessed July 1, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/relationship-between-the-mds-updrs-and-quality-of-life-in-parkinsons-disease-a-large-international-multicenter-study-of-3206-patients-the-qualpd-study/