Session Information
Date: Monday, June 20, 2016
Session Title: Epidemiology
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigate the survival and mortality of synucleinopathies 15 years of study.
Background: Limited data are available to estimate the mortality and the causes of death of Parkinson’s disease and other parkinsonism.
Methods: We used the medical records-linkage system of the Rochester Epidemiology Project to identify all subjects residing in Olmsted County, MN who received a screening diagnostic code of parkinsonism from 1991 trough 2005. A movement disorders specialist reviewed the complete medical records of each subject to confirm the presence of parkinsonism. We identified the incident cases of synucleinopathies defined as Parkinson’disease (PD), Dementia with Lewy Bodies (DLB), Parkninson Disease Dementia (PDD), and Multiple System Atrophy (MSA). We explored the risk of mortality among the different diseases, the year of survival after the diagnosis and the causes of death. We compared our patients with age and sex matched controls.
Results: In the time period from 1991 to 2005, 437 cases cases had a diagnosis of synucleinopathy (PD: 309 cases; DLB: 57; PDD: 55; MSA: 16). There was an increased risk of mortality in the subjects affected by parkinsonism as compared with the general population (Hazard ratio=1.86, 95% CI: 1.61-2.14, p<0.001); the highest risk of death was observed in MSA (HR = 7.85, 95% CI: 2.69-22.89, p<0.001), followed by PDD (HR=2.82, 95% CI: 1.80-4.40, p=<0.001), DLB (HR = 2.19, 95% CI: 2.15-4.73, p<0.001)and PD (HR = 1.42, 95% CI: 1.13-1.78, p=0.002). The mean years of survival was 7.75 (SD: 4.60) in cases and 9.64 (SD: 5.20) in controls.
Conclusions: There is an increased risk of mortality in all the synucleinopathies as compared with the general population. Patients with parkinsonism may have a reduction of the life-expectancy of about 2 years as compare with the general population.
The abstract has been submitted to the AAN 2016.
To cite this abstract in AMA style:
R. Savica, J. Bower, C. Hagen, A.J. Eric, M.M. Mielke. Survival and risk of mortality of synucleinopathies: A 15 years population-based study (1991 – 2005) [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/survival-and-risk-of-mortality-of-synucleinopathies-a-15-years-population-based-study-1991-2005/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/survival-and-risk-of-mortality-of-synucleinopathies-a-15-years-population-based-study-1991-2005/