Objective: The aim of this study attempts to explore the non-linear interaction with cross-frequency coupling in rats during the stimulation of dopamine receptors.

Background: Investigating the dynamic relationship of neural oscillation between relative brain areas has been an important approach to understand the neural network.

Method: Ten male Wistar rats with implanted a pair of 8-channel micro-wire electrode arrays in left striatum and motor cortex. We divided the rats as dopamine agonist group (n=5) and dopamine antagonist group (n=5) with different pharmacological treatment. Local field potential was acquired in pre-drug state, post-drug state (5, 30, 60, 90, 120 min.) with 5 minutes recording. Each rat underwent 3-6 times injections with interval of 2 days rest. Spectral analysis with coherence and bi-phase locking variation were performed.

Results: 1) in coherence study, increased coherence was observed in agonist group on delta (post-drug 60, 90 min), theta (post-drug 30, 60 min), and alpha (post drug 90 min). Conversely, decreased coherence was found in antagonist group on delta (post-drug 60, 90 min), theta (post-drug 60,90 min), and beta (post-drug 60, 90 min). However increased coherence in alpha (post-drug 90 min) had been observed agonist group. 2) in bi-phase locking study, agonist-induced phase locking from motor cortex to striatum was found 60-120 min post drug (delta to alpha). From striatum to motor cortex, phase locking was observed in 30-60 min post-drug (alpha, theta, delta to beta). In antagonist group, bi-directional frequency interaction had been found in 60-90 min post-drug (delta to theta).

Conclusion: oscillations between striatum and motor cortex at delta and theta bands appear significant inverse synchrony changes in identical frequency band with different stimulations. Meanwhile, different stimulations induce cross-frequency bands synchronized or interferential synchrony fluctuations in brain with direction specificity, providing a further investigation and a special point of view in intracerebral neural oscillations interaction in neural network when dopamine receptors stimulated by drugs.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/synchronization-study-of-regional-local-field-potential-in-rat-with-dopamine-receptor-stimulation/