Session Information
Date: Monday, September 23, 2019
Session Title: Ataxia
Session Time: 1:45pm-3:15pm
Location: Les Muses, Level 3
Objective: Although it is well known that patients with multiple system atrophy (MSA) cerebellar dominant type (MSA-C) show severe autonomic dysfunction, the relationship between autonomic and motor dysfunction remains uncertain. We aimed to clarify the relationship between the severity of motor dysfunctions and autonomic dysfunctions.
Background: Although it is well known that patients with multiple system atrophy (MSA) cerebellar dominant type (MSA-C) show severe autonomic dysfunction, the relationship between autonomic and motor dysfunction remains uncertain. Previously we reported that severe urinary voiding dysfunction is useful in differential diagnosis of MSA and other diseases.
Method: We retrospectively reviewed 46 patients with MSA-C diagnosed according to Gilman’s second consensus criteria. The severity of motor dysfunctions was evaluated using International Cooperative Ataxia Rating Scale (ICARS). Urodynamic study (post-void residuals (PVR) and sphincter electromyography) and head-up tilt tests were performed.
Results: The mean age of patients was 63.8 ± 8.2 years and mean disease duration was 3.0 ± 1.9 years. The mean ICARS score was 40.1 ± 14.7. The mean PVR was 119.1 ± 102 ml and the mean duration of sphincter electromyography was 9.2 ± 2.2 ms. The mean reduction in systolic (⊿sBP) and diastolic (⊿dBP) blood pressure in head-up tilt test was 24.6±2.0 mmHg and 11.1±1.3 mmHg, respectively. The correlation coefficient between ICARS and PVR was 0.093 (p = 0.539) (Figure 1a), and between ICARS and mean duration of MUPs was 0.105 (p = 0.811) (Figure 1b). A significant positive correlation (r = 0.296, p = 0.005) was noted between PVR and the mean duration of MUP (Figure 1c). The correlational coefficient between ICARS and ⊿sBP and ⊿dBP was 0.157 (p=0.316) and 0.033 (p=0.831), respectively.
Conclusion: Motor and autonomic dysfunctions are not correlated in MSA-C.
To cite this abstract in AMA style:
T. Yamamoto, Y. Yamanaka, A. Sugiyama, S. Hirano, T. Uchiyama, M. Asahina, R. Sakakibara, S. Kuwabara. The severity of motor dysfunctions and autonomic dysfunctions are not correlated in multiple system atrophy [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/the-severity-of-motor-dysfunctions-and-autonomic-dysfunctions-are-not-correlated-in-multiple-system-atrophy/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-severity-of-motor-dysfunctions-and-autonomic-dysfunctions-are-not-correlated-in-multiple-system-atrophy/