Session Information
Date: Sunday, October 7, 2018
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: This study aimed to elucidate the appropriate assessments associated with fall frequency in progressive supranuclear palsy (PSP).
Background: PSP is an adult-onset neurodegenerative disease, clinically characterized by prominent postural instability and falls, vertical supranuclear gaze palsy, and dementia. Recurrent falls is one of the cardinal features in PSP, but few studies have been reported on the assessments of fall frequency in PSP.
Methods: The subjects were PSP (n = 26, 72.9 ± 5.9years old, male/female = 19/7) with PSP staging system 4 or less. The outcomes assessments were background factors, fall frequency, gait speed, the Timed Up & Go test (TUG), the functional reach test, the pull test, the one-leg standing test, and turning 360°. Based on the PSP-rating scale I question #5 ‘Falls’, which evaluates fall frequency, the subjects were divided into two groups: high frequency fallers (HF) scored 4, with more than 30 falls per month; and low frequency fallers (LF) scored 0-3, with fewer than 30 falls per month. The logistic regression analysis was performed with significantly different factors between two groups in t-test or Mann-Whitney U test as independent variables. The correlation was calculated using the Spearman’s rank correlation coefficient. The cut-off value was calculated by the receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC). The Analysis tool was SPSS ver. 23.0, and the significance level was set at 5%.
Results: Two groups consisted of eight patients (30.8%) in HF, and eighteen (69.2%) in LF. There was a significant difference in gait speed (HF: 82.12 ± 20.08 m/min, LF: 63.78 ± 16.05 m/min, p = 0.08) and TUG (HF: 10.46 ± 2.33 sec, LF: 16.08 ± 4.23 sec, p = 0.01) between two groups. As the result of the logistic regression analysis, TUG significantly affected fall frequency (odds ratio: 0.45, 95% confidence interval: 0.213－0.952, p = 0.037), and was inversely correlated with fall frequency (r = －0.611, p = 0.001). The cut-off value of TUG was 11.38 seconds (AUC: 0.882, sensitivity: 1.000, specificity: 0.625).
Conclusions: TUG was the appropriate assessment associated with fall frequency in PSP. The faster the TUG time, the higher fall frequency was in PSP. The cut-off value was 11.38 seconds.
To cite this abstract in AMA style:
N. Matsuda, Y. Takamatsu, I. Aiba. The Timed Up & Go test (time) is inversely associated with fall frequency in progressive supranuclear palsy [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/the-timed-up-go-test-time-is-inversely-associated-with-fall-frequency-in-progressive-supranuclear-palsy/. Accessed May 19, 2025.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-timed-up-go-test-time-is-inversely-associated-with-fall-frequency-in-progressive-supranuclear-palsy/