Objective: To illuminate the respective functions of substantia nigra, striatum, cortex and cerebellum in Parkinson’s motor improvement following exercise training in a chronic MPD (MPTP induced Parkinson ‘s disease) model and provide ideas for the development of new targets for rehabilitation intervention based on exercise training.
Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder, caused by degeneration of dopaminergic neurons in substantia nigra pars compacta (SNpc). The main features of PD include motor impairment (bradykinesia, rigidity, tremor, gait dysfunction, and postural instability). Recently, increasing evidence has suggested the association between physical exercise and PD rehabilitation, but the mechanism on exercise training improving the symptoms of PD is still to be further explored.
Method: 30 animals were divided into three groups: control group, MPTP group and exercised MPTP group (PD+EX). After 10 times MPTP injections, PD+ EX was forced to run on a motorized treadmill for 12 consecutive weeks. After then, tissues were collected from cerebellum, cortex, nigra, and striatum for RNA sequence. Further, we explored the differential expression genes (DEGs) and KEGG pathways for the mechanism on exercise in PD.
Results: Exercise training improved motor dysfunction in PD mice, but failed to prevent DA neurons loss in the nigra. RNA sequence analysis showed shown that exercise training has common changes in four regions on circadian rhythm pathway and ECM-receptor interaction et al. And the least reverse genes in cerebellar region (49 genes) and the most in the striatum (221 genes) and nigra (234 genes), which indicted nigra and striatum paly important roles in exercise in PD. Further, pathway analysis identified that ingra and striatum increase expression of in synapse and relation functions on synapse. .
Conclusion: Exercise training improved motor dysfunction in PD mice, but failed to prevent DA neurons loss in the nigra. Cortex, cerebellum, nigra and striatum are involved in exercise in PD. And the nigra and striatum are the most important in contributing to Improvement of motor symptoms in PD.
To cite this abstract in AMA style:
T. Tong, Z. Zhang, Z. Zhang, H. Hu, L. Li, J. Jin. The Transcriptome from Multiple Regions of the MPTP-induced Parkinson’s disease Mouse Brain after exercise [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/the-transcriptome-from-multiple-regions-of-the-mptp-induced-parkinsons-disease-mouse-brain-after-exercise/. Accessed June 15, 2025.« Back to MDS Virtual Congress 2021
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-transcriptome-from-multiple-regions-of-the-mptp-induced-parkinsons-disease-mouse-brain-after-exercise/