Session Time: 1:15pm-2:45pm
Location: Les Muses Terrace, Level 3
Objective: To investigate longitudinal cortical thinning (CT) in Parkinson’s disease (PD) patients with normal cognition (PD-CN), stable mild cognitive impairment (PD-MCIs), and patients who convert to MCI (PD-MCIc) and dementia (PD-Dc).
Background: Identification of biomarkers underlying cognitive decline in PD may facilitate the ongoing effort of identifying patients at risk of dementia.
Method: We recruited 114 patients with known cognitive outcome after 4 years of follow-up (37 PD-CN, 21 PD-MCIs, 36 PD-MCIc, 21 PD-Dc) and 39 healthy controls (HC). Patients underwent four visits, including neuropsychological/clinical assessments and MRI. We investigated cortical thickness (CT) at baseline and its progression over time.
Results: At baseline, compared to HC and PD-CN patients, PD-Dc, PD-MCIc and PD-MCIs patients showed greater cortical damage in the entire parietal lobe. Overtime, PD-CN and PD-MCIc accumulated the most damage in frontal and parietal regions. PD-MCIs and PD-Dc patients showed similar patterns of thinning in the temporal and parietal lobes. The posterior cingulate cortex and supramarginal gyrus were affected overtime only in the ‘converter’ groups. TimeXgroup interaction showed that (vs the other patient groups): PD-Dc and PD-CN accumulated the least damage; PD-MCIc had specific CT accumulation in the posterior cingulate cortex, supramarginal and parahippocampal gyri; PD-MCIs showed a pattern of damage in fronto-temporo-parietal regions, bilaterally.
Conclusion: CT accumulation seems to be more prominent in the initial stages of PD cognitive decline. The involvement of specific temporo-parietal regions is associated with the conversion to a more severe stage of cognitive impairment. In PD, CT of crucial brain regions may be powerful for the identification of patients at risk of developing dementia. Supported by: Ministry of Education and Science, Republic of Serbia (Grant#175090).
To cite this abstract in AMA style:E. Canu, F. Agosta, T. Stojković, S.. Basaia, I. Stankovic, V. Markovic, I. Petrović, E. Stefanova, V. Kostic, M. Filippi. Tracking cortical changes throughout cognitive decline in Parkinson’s disease: a longitudinal MRI study [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/tracking-cortical-changes-throughout-cognitive-decline-in-parkinsons-disease-a-longitudinal-mri-study/. Accessed December 1, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/tracking-cortical-changes-throughout-cognitive-decline-in-parkinsons-disease-a-longitudinal-mri-study/