Objective: To estimate the incidence of in-hospital admissions of Parkinson´s disease (PD) in Spain during the last decade (2010-2019) and describe the epidemiology of these hospitalizations.

Background: Parkinson´s disease (PD) is the second most common neurodegenerative disease worldwide and its prevalence will double by 2030 (1). PD also increases hospital admission rates and healthcare costs (2).

Method: This is a retrospective observational study using the Spanish National Hospital Discharge Database (SNHDD) that analyses the trends of PD hospitalizations in Spain during the last decade (2010-2019). PD diagnosis was classified as a primary/secondary diagnosis in relation to hospital admission. Data such as age, sex, comorbidities (Charlson Comorbidity Index, CCI) and in-hospital mortality (IHM) were collected.

Results: The total number of hospitalizations during 2010-2019 was approximately 410000. The proportion of women was 46.88% (SD =8.77). The proportion of male sex increased progressively over time (52.29% in 2010-2011 compared to 54.12% in 2018-2019). There was also a slight increase in age (79.14 years in 2010-2011 vs. 80.05 in 2018-2019; p<0.001) and in comorbidities (mean CCI 1.55 in 2010-2011 vs. 1.79 in 2018-2019, p<0.001). The overall IHM for PD patients in Spain in the last decade was 10.48% (42,897 in-hospital deaths), showing a slight increase over time (10.4% in 2010-2011 vs 10.87% in 2018-2019, p<0.001). Most patients had PD as a secondary diagnosis (95.84%) in relation to hospitalization, with increasing trends in age, male sex, comorbidities and IHM. Among hospitalizations of PD as a primary diagnosis (4.16%), comorbidity and age remained unchanged for both sexes, but IHM also increased (2.34% in 2010-2011 vs 3.59% in 2018-2019, p=0.031). Figures 1 and 2 shows the jointpoint analysis of hospitalizations regarding sex and primary/secondary diagnosis over the study period (2010-2019).

Conclusion: PD has increased as a primary and secondary diagnosis among hospitalizations in Spain during the last decade (2010-2019). There has been an increase in mean age, male sex, comorbidities and IHM among patients hospitalized with PD.

References: (1) Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 68 (2007):384–6
(2) Gil-Prieto R, Pascual-Garcia R, San-Roman-Montero J, Martinez-Martin P, Castrodeza-Sanz J, Gil-de-Miguel A (2016) Measuring the Burden of Hospitalization in Patients with Parkinson´s Disease in Spain. PLoS ONE 11(3): e0151563.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/trends-in-incidence-of-hospitalizations-in-parkinsons-disease-in-spain-2010-2019/