Date: Monday, June 5, 2017
Session Title: Parkinsonism, MSA, PSP (Secondary and Parkinsonism-Plus)
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective: The aim of this study was to determine the neuropsychiatric profile in our cohort of PSP patients and their dynamic changes over a follow-up period of one year, as well as to examine the effects of different variables on these changes.
Background: Several studies analyzed behavioral and neuropsychiatric symptoms of PSP and emphasized depression and/or apathy as the most prevalent. Moreover, the clinicopathological studies of PSP cases revealed that in some of them behavioral features could predominate the clinical presentation, with considerable overlap with a differential diagnosis of frontotemporal dementia.
Methods: A total of 59 patients were assessed at baseline, while 25 of them were accessible after one year of the follow-up. The detailed demographic and clinical interview was performed and appropriate motor and cognitive scales were applied. The presence of psychiatric symptoms was assessed using the Neuropsychiatric Inventory (NPI). In addition, depressive and anxiety symptoms, as well as apathy, were evaluated by the Hamilton Depression Rating Scale, the Beck Depression Inventory, Hamilton Anxiety Rating Scale, and the Apathy Scale, respectively. Statistical analysis of baseline data included both correlation and linear univariate and multivariate regression analyses. The value of changes of selected variables over one-year follow-up period, was quantified using the Wilcoxon signed ranks test. The level of these differences was calculated as an effect size.
Results: The most common symptoms were apathy and depression, which were also found to be the independent determinants of increased NPI total score in the longitudinal study. Apathy deteriorated most profoundly over the follow-up period.
Conclusions: Our study was one of few longitudinal studies on PSP, which provided some new insights into dynamic changes of the neuropsychiatric profile of these patients. It implied that apathy was a predominant feature of the behavior profile of PSP. Finally, the NPI seemed to be a sensitive measure of behavioral changes in PSP and could be included among potential outcome measures in future clinical trials in PSP.
To cite this abstract in AMA style:M. Jecmenica Lukic, T. Pekmezovic, I. Petrovic, A. Tomic, M. Svetel, V. Kostic. Use of the Neuropsychiatric Inventory to Characterize the Course of Neuropsychiatric Symptoms in Progressive Supranuclear Palsy [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/use-of-the-neuropsychiatric-inventory-to-characterize-the-course-of-neuropsychiatric-symptoms-in-progressive-supranuclear-palsy/. Accessed December 2, 2023.
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