Session Information
Date: Monday, June 20, 2016
Session Title: Parkinson's disease: Non-motor symptoms
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To evaluate (1) prevalence of peripheral neuropathy and (2) usefulness of known neuropathy scores in patients with Parkinson’s disease (PD).
Background: Peripheral neuropathy has recently described in higher proportions in patients with PD than in normal controls (37.8% vs 8.1%). However, peripheral neuropathy and neuropathic pain is often under reported, under diagnosed and under treated in clinical practice because both physicians and patients may focus on the motor symptoms of PD. There are several tools to detect neuropathy and to score severity of neuropathic pain including Total Neuropathy Score revised (TNSr), Korean Neuropathic Questionnaire (KNQ) and Tronto Clinical Scoring System (TCSS) but it is unclear whether is use can be extended to patients with PD.
Methods: We performed a cross-sectional study of 47clinically and Dopamine transporter scan (DaT scan) positive patients using TNSr, KNQ and TCSS. The prevalence of peripheral neuropathy was determined by the clinical symptom, neurological examination and abnormality in their nerve conduction study. We excluded patients who had diabetes, lumbosacral radiculopathy and autoimmune related disorders including thyroid disease. The IPD group was divided into 2 groups (PD with and without peripheral neuropathy). ROC curves, sensitivity and specificity were determined.
Results: 17 of 47 PD patients (36%) had clinically peripheral neuropathy. There was no statistical difference between the 2 groups concerning sex, LED, UPDRS III, vitamin B12, and homocysteine. Analysing areas under the ROC curve for the neuropathy screening tools, all neuropathy tools showed good accuracy. TNSr [AUC=0.790, r=0.007] showed higher sensitivity (66.8%) and specificity (81.8%) than KNQ [AUC=0.756, r=0.015] and TCCS (AUC=0.720, r=0.037) at a cut-off point 7.
Conclusions: TNSr test may be extended in screening for peripheral neuropathy in patients with PD. And it is also useful tool in comparison with KNQ and TCSS.
To cite this abstract in AMA style:
P.W. Ko, J.S. Park, K. Kang, H.W. Lee. Usefulness of total neuropathy score revised as a screening tool of peripheral neuropathy in patients with Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/usefulness-of-total-neuropathy-score-revised-as-a-screening-tool-of-peripheral-neuropathy-in-patients-with-parkinsons-disease/. Accessed June 14, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/usefulness-of-total-neuropathy-score-revised-as-a-screening-tool-of-peripheral-neuropathy-in-patients-with-parkinsons-disease/