Date: Thursday, June 23, 2016
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: The objetive of our study is to assess the utility of the subtypes IgG direct Coombs test (DCT) in maintenance apomorphine treatment without risk of hemolytic anemia (HA). The subtypes 1 and 3 are associated with high risk. However, subtypes 2 and 4 have very low risk of this complication.
Background: An undesired complication in the management of patients with advanced Parkinson’s disease (APD) in treatment with continuous infusion of apomorphine is HA.
Methods: Between 2011-2015 we have implanted 22 infusion sets and used the DCT with Ag as a method of control. This is a cohort of 22 patients with APD (7 women and 15 men) with a mean age 61.3 (range 52-85). The mean progression of Parkinson’s disease was 15 years (range 11-26) with Hohen and Yahr stage at the time of implantation between 2.5-4.5 (mean 3.18). The flow of perfusion ranged between 3.09-4.17 mg per hour and the duration between 14 to 24 hours a day. As an added standard Levodopa medication alone they had an average of 1044.7 mg. All they are made blood controls and DCT every 6 months.
Results: In four patients aged between 56 and 76 years DCT antigens were detected with positive IgG. Three of them maintenance the bomb because had the subtypes 2 and/or 4. The mean of treatment was 26 months (range 15-43). We have made controls every month (range 4-10 months) without complications.
Conclusions: Applying IgG subtypes is more sensitive than DCT simple and allows drug withdrawal avoiding the possibility of HA or maintenance apomorphine treatment with very low risk.
To cite this abstract in AMA style:P. Sanchez-Lozano, E. Suarez, R. Ribacoba. Utility of IgGs subtypes in hemolytic anemia prevention and treatment maintenance in patients treated with continous infusion of apomorphine [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/utility-of-iggs-subtypes-in-hemolytic-anemia-prevention-and-treatment-maintenance-in-patients-treated-with-continous-infusion-of-apomorphine/. Accessed September 23, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/utility-of-iggs-subtypes-in-hemolytic-anemia-prevention-and-treatment-maintenance-in-patients-treated-with-continous-infusion-of-apomorphine/