Objective: to study the correlation between vitamin D levels (deficiency) and clinical presentations in patients with Parkinson’s disease

Background: previous studies throughout the world have shown that patients with Parkinson’s disease have low serum vitamin D concentrations and the severity of the disease depends on the deficiency of vitamin D

Method: 127 patients with Parkinson’s disease were ranged by gender, age, stage of the disease. We used the following tests and questionnaires: Schwab и England scale, 1969; Hoehn–Yahr scale, 1967;  MDS Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) 2015; Beck Depression Inventory 1966; HADS, Parkinson’s Disease Questionnairy – 39;  non-motor symptoms questionnaire.
Ten biomarkers were examined in serum from these patients: level of 25-OH vitamin D (25-OH vitamin D, 25(OH)D, 25-hydroxycalciferol), blood protein, basic phosphatase, ionized calcium, calcium total, phosphorus, thyroid stimulating hormone, free thyroxine, parathyroid hormone, calcitonin.
The densitometry also was provided.

Results: working patients with Parkinson’s disease have the higher level of serum vitamin D than patients with Parkinson’s disease who don’t work (p=0.024);
the older patients in debut with Parkinson’s disease are the lower level of serum vitamin D is (p=0.047);
the older patients with Parkinson’s disease who came first are the lower level of serum vitamin D is  (p=0.0378);
the lower level of serum vitamin D is the higher stage of Parkinson’s disease according to Hoehn-Yahr scale is (p=0.0246);
the lower level of serum vitamin D is the more severe non-motor symptoms in patients with Parkinson’s disease are (p=0.033);
the lower level of serum vitamin D is the more severe the cognitive impairment is (p=0.007);
the lower level of serum vitamin D is the longer patients with Parkinson’s disease take levodopa (p=0.0092)

Conclusion: this study is illustrated the importance of understanding the correlation between the deficiency of vitamin D and the severity of Parkinson’s disease. In our study special attention is paid to non-motor symptoms.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/vitamin-d-and-parkinsons-disease/