Session Information
Date: Monday, September 23, 2019
Session Title: Other
Session Time: 1:45pm-3:15pm
Location: Agora 2 West, Level 2
Objective: To explore the usefulness of wearable sensor data to inform treatment decisions in PD.
Background: Wearable sensors are becoming increasingly incorporated into clinical care surrounding Parkinson’s Disease (PD). Although the value of wearable sensors for monitoring of dopamine replacement therapy (DRT) has been shown in cross-sectional settings, its use in longitudinal clinical setting remains largely unexplored.
Method: Longitudinal analysis of wearable sensor data (Parkinson’s Kinetigraph; PKG) in an unselected cohort of 100 patients with PD. Wearable sensor data included bradykinesia (BK) and dyskinesia (DK) scores. For each patient, demographic data and changes to dopaminergic medication regime were recorded and PKG data was available at baseline and at 3 months interval. Patients who had their medication regime changed (group 1, n=29) were compared to those with no change (group 2, n=71) using Mann-Whitney U test and intergroup changes were assessed by the Wilcoxon signed rank rest. Data is presented as mean ± standard deviation.
Results: At baseline, patients (57 male, 43 female) had an average age of 66.2 ± 9.3 years, and disease duration of 8.8 ± 6.4 years. The cohort was followed up for 2.9 ± 0.8 months. No differences were observed in baseline demographics between groups . At baseline, average BK was 29.6 ± 8.8 (group 1) and 27.3 ± 8.6 (group 2) (p=0.26). Average DK for group 1 was 3.0 ± 3.9 and 5.9 ± 18.2 for group 2 (p=0.68). In group 1, BK scores significantly improved (p=0.001) while DK worsened (p=0.011), yet still remaining within the non-troublesome range. No group differences were observed in BK and DK scores at follow-up (p≥0.34).
Conclusion: The study shows that wearable sensors could be sensitive to key motor changes after DRT and may add to implementation of value based healthcare with remote monitoring in future.
To cite this abstract in AMA style:
A. Podlewska, D. van Wamelen, A. Sauerbier, V. Leta, D. Trivedi, M. Parry, K. Ray Chaudhuri. Wearable sensor use and monitoring effect of dopamine replacement therapy on motor parameters in a real life clinical setting [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/wearable-sensor-use-and-monitoring-effect-of-dopamine-replacement-therapy-on-motor-parameters-in-a-real-life-clinical-setting/. Accessed June 14, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/wearable-sensor-use-and-monitoring-effect-of-dopamine-replacement-therapy-on-motor-parameters-in-a-real-life-clinical-setting/