Long-term effects of levodopa/carbidopa intestinal gel infusion in advanced Parkinson’s disease patients: Dutch multicenter retrospective cohort study
Objective: To determine the long-term outcomes of levodopa/carbidopa intestinal gel infusion (LCIG) in advanced Parkinson's disease (PD) patients. Background: LCIG was introduced in the Netherlands…Development of a nanoherbaceutical formulation containing compound extracts from huperzia serrata, mucuna pruriens and withania somnifera for the prevention and treatment of Parkinson’s disease
Objective: We developed the nanoherbaceutical formulation and evaluated against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson's disease (PD) model. Background: PD is a progressive neurodegenerative disorder allied…Influence of treadmill gait training with additional load on motor function, postural instability and history of falls for individuals with Parkinson’s disease: A randomized clinical trial
Objective: The objective of this study was to evaluate the effects of additional load (5% and 10%) with treadmill gait training on the overall motor…Effects of levodopa on adaptation of reactive stepping in people with Parkinson’s disease
Objective: Participants with PD were able to improve postural stepping responses with practice and this learning was improved by levodopa. Background: Protective steps in response…Levodopa/carbidopa intestinal gel, neuropathy, and B-vitamins – Is there an association?
Objective: To assess the frequency of neuropathy and its neurophysiological characteristics in orally and levodopa/carbidopa intestinal gel (LCIG) treated patients with advanced idiopathic Parkinson´s disease…Peri-operative dopaminergic replacement protocol with rotigotine in Parkinson’s disease patients
Objective: To evaluate the accomplishment of a peri-operative dopaminergic replacement protocol established in our centre from 2011 to 2014, and analyse the main factors associated…Exploratory efficacy of opicapone in fluctuating Parkinson’s disease patients at different stages of symptom progression
Objective: Evaluate the efficacy of opicapone (OPC) in fluctuating Parkinson's disease patients at different stages of symptom progression over a 14-15 week treatment period. Background:…Continuous subcutaneous delivery of solubilized carbidopa improves the pharmacokinetic profile of levodopa
Objective: To characterize the peripheral pharmacokinetics and CNS metabolism of levodopa during continuous subcutaneous delivery of solubilized carbidopa. Background: Although many commercial levodopa formulations include…Effects of plantar automated mechanical stimulation (AMPS) on motor symptoms of patients with advanced Parkinson’s disease: Preliminary data of a double blind randomized clinical trial
Objective: To evaluate the effect of one session treatment with autometed mechanical peripheral stimulation (AMPS) on gait and motor functions of patients with advanced Parkinson's…Long-term safety of levodopa-carbidopa intestinal gel from an ongoing, open-label, phase 3 continued access to treatment study in advanced Parkinson’s disease patients
Objective: To assess the safety and tolerability of levodopa-carbidopa intestinal gel (LCIG, designated in the United States as carbidopa-levodopa enteral suspension) in advanced Parkinson's disease…
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