Are Parkinson’s disease futility studies futile?
Objective: Revisit Phase II futility studies. Background: Published results of a Phase III trial of creatine monohydrate for Parkinson's disease (PD) in the presence of…DBS related on-state freezing of gait – A case series
Objective: To present the first ever case series of on-state freezing of gait (FOG) after DBS surgery using dose-cycle gait evaluation. Background: FOG is categorized…Can stimulation of deep brain tissue improve the expression of the mouth in Parkinson’s disease patients?
Objective: To observe if stimulation of deep brain tissue can improve expression of the mouth in Parkinson's disease patients. Background: Masked facies or hypomimia is…Electric stimulation of the nucleus subthalamicus is able to modulate prepulse inhibition. A pilot study in Parkinson´s disease
Objective: To evaluate if prepulse inhibition (PPI) is influenced by electrical stimulation in the Nucleus subthalamicus (STN) of patients with Parkinson´s disease (PD). Background: PPI…Deep brain stimulation in a Parkinsonian patient with sever psychiatric complication
Objective: In order to know what degree of psychiatric complication is hazard to deep brain stimulation (DBS) in patients with Parkinson's disease, we report and…Traditional trial-and-error versus neuroanatomical-3D-image software-assisted deep brain stimulation programming in patients with Parkinson’s disease
Objective: To compare traditional trial-and-error with neuroanatomical-3D-image software-assisted deep brain stimulation (DBS) programming in patients with Parkinson's disease (PD) treated with subthalamic nucleus (STN) DBS.…Recharge frequency is not driven by therapy power usage in patients implanted with rechargeable deep brain stimulation systems
Objective: To explore the relationship between recharge frequency and therapy power usage in patients with rechargeable deep brain stimulation (DBS) devices. Background: Advancements in DBS…Unilateral dual lead thalamic deep brain stimulation improves refractory essential tremor
Objective: To report on the results of utilization of multiple ipsilateral leads for DBS treatment of essential tremor. Background: Thalamic VIM DBS (deep brain stimulation)…An international, randomized, sham controlled trial of focused ultrasound thalamotomy for essential tremor
Objective: To determine efficacy and safety of unilateral focused ultrasound thalamotomy for refractory essential tremor. Background: Recent advances in ultrasound transducer technology allow ultrasound to…Glucagon-like peptide 1 analogues for treating multiple system atrophy: A translational study
Objective: (i) To determine whether insulin resistance is a neuropathological feature of multiple system atrophy (MSA) and, (ii), to evaluate the therapeutic efficacy of the…
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