Quantifying daily living transitions in patients with Parkinson’s disease using a body-fixed sensor
Objective: To test whether measures of everyday sit-to-walk and walk-to-sit differ between patients with Parkinson's disease (PD) and healthy older adults (HOA) and between mild…Mitochondrial-nuclear interplay in single respiratory chain-deficient Parkinson’s disease neurons
Objective: To explore the role of the mitochondrial DNA (mtDNA) in the development of respiratory chain complex (CI-IV) deficiencies in the substantia nigra (SN) of…Optimization of 6-hydroxydopamine animal model of early stage Parkinson´s disease for the assessment of neurorestorative therapies
Objective: To optimize a simple unilateral partial 6-hydroxydopamine (6-OHDA) lesion protocol that would produce 40-60% striatal dopamine (DA) depletion with detectable motor deficits and to…Subthalamic nucleus activity during virtual reality provoked lower limb freezing in a patient with Parkinson’s disease and freezing of gait
Objective: Record subthalamic nucleus activity in a Parkinson's disease patient with gait freezing while they perform a virtual reality walking task during DBS surgery. Background:…Protein levels of SV2A and VGLUT1 in brain tissue from patients with Parkinson’s disease, dementia with Lewy bodies and Alzheimer’s disease
Objective: The objective of this study was to investigate whether SV2A and/or VGLUT1 are suitable as markers for synaptic degeneration in neurodegenerative disorders and could…Disruption of circadian rhythm function and anti-oxidation via SIRT1-BMAL1 pathway in 6-OHDA induced Parkinson’s disease model
Objective: Our aim is to investigate whether the altered expression of clock genes is associated with the dysfunction of the anti-oxidative ability in Parkinson's disease.…Saliva swallowing frequency measured using 24-hours ambulatory impedance-pH monitoring in patients with Parkinson’s disease and drooling
Objective: To assess the feasibility of using 24-hours ambulatory impedance-pH monitoring (24-hAlpHM) to precisely measure saliva swallowing frequency (SSF) in patients with Parkinson's disease (PD).…Cortical impairment as marker of dementia risk in probable REM sleep behavior disorder in Parkinson’s disease
Objective: To assess utility of Parkinson's disease-cognitive rating scale (PD-CRS) to detect Mild cognitive impairment (MCI) and dementia risk in a Parkinson's disease (PD) subpopulation.…Relative hypoglycemia induces acute chorea followed by chronic parkinsonism in a diabetic patient on hemodialysis: A case with sequential clinico-radiological correlate
Objective: To present a sequential clinico-radiological study of a diabetic patient on hemodialysis who developed acute chorea followed by chronic parkinsonism. Background: Hyperglycemic chorea is…Ciprofloxacin as the cause of syndroma extrapiramidale
Objective: Ciprofloxacin in rare cases can cause paresthesia, dysesthesia, hypoesthesia, tremor, convulsions, dizziness . Background: The patient, 22 years old, comes in the emergency room,…
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