Impact of prolonged temporal discrimination threshold on finger movements of Parkinson’s disease
Objective: In present study, we investigated the impact of temporal discrimination threshold (TDT) prolongation on simple repetitive finger tapping and dexterous finger movement in patients…Lessons learned from the Nilotinib trial: Cardio-vascular conditions in parkinsonism
Objective: A retrospective records review of 9 patients that failed screening for a clinical trial was performed to examine the co-morbid cardiac manifestations of PD…Alpha-synuclein – super-resolution microscopy reveals potential new role of alpha-synuclein at the pre-synapse
Objective: Alpha-synuclein is a major key player in Parkinson's disease, however its physiological function still remains elusive. Using super-resolution microscopy this study aims to analyse…The effect of STN-DBS on movement initiation control is modulated by the noradrenergic system: Evidence of an interaction from a combined pharmacological/DBS/EEG study
Objective: Assessing the role of the noradrenergic system underlying the effect of subthalamic nucleus stimulation (STN-DBS) on akinesia. Background: Slowness in movement initiation, associated with…Treatment of OFF episodes in Parkinson’s disease: An evaluation of patient and caregiver insights
Objective: Evaluate patient and caregiver opinions into the treatment of OFF episodes in patients with Parkinson's disease (PD). Background: OFF episodes are fairly common in…Synaptic homeostasis in Parkinson’s disease: An high-density EEG study in different stage of the disease
Objective: In order to corroborate these findings, we submitted 29 Parkinson's disease (PD) patients with different stage of disease to an all-night high-density EEG (hd-EEG)…Detailed proteomic analysis of early PD brain highlights altered expression of mitochondrial proteins as an important event in sporadic PD
Objective: To uncover early pathogenic events occurring prior to neuronal loss and Lewy body formation in human PD brain. Background: In PD, pathological changes spread…Lrrk2 alleles modify host response to microbial infections
Objective: The mechanisms by which allelic changes in LRRK2 modulate the susceptibility to Parkinson's disease, Crohn's disease and leprosy remain unknown. We hypothesized that leucine-rich…Incidental finding of drug-induced movement disorder
Objective: Recognizing a drug-induced movement disorder is critical as only stopping using over the counter dopamine-blocking medications such as metoclopramide can reverse or improve clinical…Alcohol-responsive action myoclonus of the leg in prostate cancer: A novel paraneoplastic syndrome
Objective: To describe two patients with prostate cancer and identical phenotypes of likely paraneoplastic unilateral leg myoclonus. Background: Paraneoplastic movement disorders (PMDs) in prostate cancer…
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