Novel small molecules targeting alpha-synuclein aggregation for the treatment of Parkinson’s disease
Objective: To develop novel, small molecular weight compounds, that can interfere with the aggregation process of alpha-synuclein (aSyn), as disease modifying agents. Background: The aggregation…Dopamine dysregulation syndrome /DDS/ in LCIG infusion: Successful treatment without interrupting the pump therapy
Objective: Here we report the case of a 49-year-old man with a 19 years history of PD presenting DDS while he was on LCIG therapy.…Motor fluctuations in relation to plasma concentrations following a single-dose of levodopa/carbidopa microtablets in advanced Parkinson’s disease
Objective: The aim of this study was to characterize the levodopa and carbidopa plasma concentration in relation to blinded motor function ratings. This is a…Feasibility, safety and effects of a group intervention based on European physiotherapy guideline for Parkinson´s disease
Objective: To assess the feasibility, safety and effects of an group intervention based on European Physiotherapy Guideline. Background: Studies suggest that exercise may contribute to…Contributions of sensorial feedback to gait in Parkinson’s disease
Objective: To evaluate the integration of optic flow and proprioception when people with Parkinson's disease (PD), under and without dopaminergic medication effects, and matched-control group…Exercise-induced adaptive neuroplasticity in the MPTP mouse model of Parkinson’s disease
Objective: To increase our understanding of how physical exercise may drive adaptive neuroplasticity in a mouse model of Parkinson's disease (PD). Background: PD is a…Acute admissions in people with Parkinson’s – More than just frailty
Objective: Review if admissions of People with Parkinson's(PwP) to hospital is directly related to their Parkinson's symptoms. Assess if medications are received on time. Explore…Beta – blockers worsen vascular parkinsonism in patients with concomitant coronary heart disease
Objective: Our primary aim was to study the effect of beta - blockers on the dynamics of extrapyramidal disorders in patients suffering from coronary heart…Therapeutic protocol for Parkinson’s patient with freezing based on action observation plus sonification: Preliminary results
Objective: To evaluate the effects of a novel experimental protocol to treat patients with Parkinson's disease (PwP) and freezing of gait (FoG), using functional, and…Apraclonidine in the treatment of ptosis
Objective: To describe the improvement in ptosis with apraclonidine in patients with botulinum toxin (BoNT) induced ptosis. Background: Ptosis is a manifestation of a variety…
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