Alpha-synuclein gene variants may predict neurostimulation outcome
Objective: We aim to predict both treatment efficacy and disease progression in PD patients with subthalamic nucleus deep brain stimulation therapy (STN-DBS) by genotyping of…Impairments in trunk muscle function influence head and trunk stability during walking in Parkinson’s disease fallers
Objective: This prospective study aimed to evaluate the relationship between impaired trunk muscle function, segmental coordination and future falls in people with Parkinson's disease (PD).…Quantifying daily living transitions in patients with Parkinson’s disease using a body-fixed sensor
Objective: To test whether measures of everyday sit-to-walk and walk-to-sit differ between patients with Parkinson's disease (PD) and healthy older adults (HOA) and between mild…Mitochondrial-nuclear interplay in single respiratory chain-deficient Parkinson’s disease neurons
Objective: To explore the role of the mitochondrial DNA (mtDNA) in the development of respiratory chain complex (CI-IV) deficiencies in the substantia nigra (SN) of…Optimization of 6-hydroxydopamine animal model of early stage Parkinson´s disease for the assessment of neurorestorative therapies
Objective: To optimize a simple unilateral partial 6-hydroxydopamine (6-OHDA) lesion protocol that would produce 40-60% striatal dopamine (DA) depletion with detectable motor deficits and to…Subthalamic nucleus activity during virtual reality provoked lower limb freezing in a patient with Parkinson’s disease and freezing of gait
Objective: Record subthalamic nucleus activity in a Parkinson's disease patient with gait freezing while they perform a virtual reality walking task during DBS surgery. Background:…Protein levels of SV2A and VGLUT1 in brain tissue from patients with Parkinson’s disease, dementia with Lewy bodies and Alzheimer’s disease
Objective: The objective of this study was to investigate whether SV2A and/or VGLUT1 are suitable as markers for synaptic degeneration in neurodegenerative disorders and could…Disruption of circadian rhythm function and anti-oxidation via SIRT1-BMAL1 pathway in 6-OHDA induced Parkinson’s disease model
Objective: Our aim is to investigate whether the altered expression of clock genes is associated with the dysfunction of the anti-oxidative ability in Parkinson's disease.…Saliva swallowing frequency measured using 24-hours ambulatory impedance-pH monitoring in patients with Parkinson’s disease and drooling
Objective: To assess the feasibility of using 24-hours ambulatory impedance-pH monitoring (24-hAlpHM) to precisely measure saliva swallowing frequency (SSF) in patients with Parkinson's disease (PD).…Cortical impairment as marker of dementia risk in probable REM sleep behavior disorder in Parkinson’s disease
Objective: To assess utility of Parkinson's disease-cognitive rating scale (PD-CRS) to detect Mild cognitive impairment (MCI) and dementia risk in a Parkinson's disease (PD) subpopulation.…
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