Assessment of Parkinson’s disease risk loci as DNA methylation quantitative trait loci
Objective: To gain potential mechanistic insight into the pathogenesis of Parkinson's disease (PD), a map of DNA methylation in normal human brain assessing 486,428 CpG…Substantial motor and non-motor symptoms in children and adults with classical galactosemia and organic acidurias
Objective: To investigate the prevalence of movement disorders (MDs), their impact on quality of life (QoL) and accompanying non-motor symptoms in patients with classical galactosemia…Parkinson’s disease-associated Miro1 mutants cause mitochondrial dysfunction
Objective: In the present study we dissected the role of the first PD-associated mutations in RhoT1, the gene encoding for Miro1. Background: Commonly involved pathogenic…Mitochondrial dysfunction in skin fibroblasts from single heterozygous ATP13A2 (PARK9) mutation carriers
Objective: To investigate the pathogenic effect of single heterozygous mutations in ATP13A2, we determined the function and morphological changes of mitochondria in skin fibroblasts derived…Differences of gut bacterial community relate to pathology progress in Parkinson’s disease
Objective: The aim of this study is to examine whether intestinal microbiota correlate with progression of clinical severity and serum inflammation marker. Background: Constipation is…Localization and functional study of synaptic vesicle protein synaptogyrin-3 (SYNGR3) on dopaminergic neuronal system
Objective: To investigate (1) the intracellular localization of SYNGR3 and its interaction with dopamine transporter (DAT); (2) how expression of SYNGR3 in neurons affects dopamine…Kinematic analysis of repetitive finger movements and the effects of selegiline and pramipexole in early Parkinson’s disease
Objective: To characterize the features of bradykinesia in newly diagnosed patients with Parkinson's disease (PD) and the response to pramipexole and selegiline administration. Background: Motor…Modulation of microglia function in the prion-like spreading of α-synuclein in the murine brain
Objective: We aimed to analyze the influence of two microglia-related pathways on the accumulation of α-synuclein aggregates and neurodegeneration after intracerebral injection of sonicated murine…F1 crossbreds of C57BL/6 and CD-1 mice demonstrate resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced nigral neurodegeneration
Objective: To establish the neural basis of varying susceptibility to MPTP in MPTP resistant CD-1 mice, susceptible C57BL/6 mice and their crossbreds; simulating the variable…Vagus nerve stimulation as a novel treatment strategy for Parkinson’s disease
Objective: To assess the therapeutic potential of chronic vagus nerve stimulation (VNS) to attenuate the behavioral and neuronal deficits observed in Parkinson's disease (PD) by…
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