The application of mobile health technology to increase physical activity in persons with Parkinson’s disease
Objective: To investigate the safety, acceptability and preliminary evidence of efficacy of a mobile health (mhealth) mediated home-based exercise program to increase physical activity in…Biseptol a new antiParkinsonian agent?
Objective: To evaluate the possible effect of combined intake of levodopa/carbidopa and trimethoprim/sulfamethoxazole on the duration of ON/OFF periods in a PD patient. Background: Drug…When is the worst period of nocturnal hypokinesia in Parkinson’s disease? A sensor-based analysis
Objective: To quantify the number of turning in bed throughout the night as a determinant of the severity of nocturnal hypokinesia. Background: Nocturnal hypokinesia or…Levodopa, placebo and rotigotine change biomarker levels for oxidative stress
Objective: The objective was to investigate the influence of the D1 receptor agonists levodopa and rotigotine compared with placebo on homocysteine and cysteinyl-glycine in plasma…Combined stimulation of STN and SNr for resistant freezing of gait in Parkinson’s disease (STN+SNr) – A multicenter randomized controlled trial
Objective: 54 patients with idiopathic Parkinson's disease and freezing of gait resistant to subthalamic nucleus stimulation and dopaminergic medication will be included into this German-wide…Strategies to improve drug development efficiency through regulatory interactions, minimizing the placebo effect and improving data integrity within a phase 3 study of tozadenant in Parkinson’s disease patients with motor fluctuations (TOZ-PD)
Objective: To identify and implement strategies to improve the efficiency of drug development in Phase 3 studies. Background: Conducting global clinical trials can be challenging,…A multi-site survey of Parkinson’s disease deep brain stimulation center best practice: moving toward a standard of care for DBS
Objective: To survey how Deep Brain Stimulation (DBS) Centers handle referrals and peri-operative (surgical and non-surgical) treatment of persons with Parkinson's disease (PD). Background: Currently…Spinal cord stimulation improves freezing of gait in Parkinson’s disease in chronic implanted stn-dbs patients: A case report
Objective: The aim of our study was to evaluate further the potential role of spinal cord stimulation (SCS) as a treatment for gait disturbances and…Can a leopard changes its spots? How impulse control disorder affects subthalamic stimulation paradigm
Objective: To study the effect of previous impulse control disorders (ICD) on subthalamic nucleus deep brain stimulation (STN-DBS) programming in subjects with Parkinson's disease (PD).…Impact of the combined depletion of monoamines on the effectiveness of deep brain stimulation of the subthalamic nucleus
Objective: To investigate the involvement of combined depletions of dopamine, norepinephrine and serotonin in the manifestation of motor and non-motor deficits and their impact on…
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