The systemic synuclein sampling study (S4)
Objective: The Systemic Synuclein Sampling Study (S4) is designed to characterize the distribution of alpha-synuclein (α-syn) pathology in multiple tissues and biofluids in Parkinson's disease…Bilateral subthalamic nucleus deep-brain stimulation (STN-DBS) in the management of idiopathic Parkinson’s disease: Results of our first 20 cases
Objective: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely accepted as a treatment for advanced Parkinson's disease (PD). However, published studies were…Two years after unilateral Forel’s H campotomy for Parkinson’s disease: Quality of life, motor and cognitive outcomes of eleven patients
Objective: To provide a thorough assessment of the effects of unilateral Forel's H campotomy on Parkinson's disease patients. Background: Since its proposal in 1963, Forel's…Role of contact polarity on therapeutic impedances at two deep brain stimulation (DBS) targets
Objective: To demonstrate the role of contact polarity on therapeutic impedances at two DBS targets. Background: Neuromodulation with DBS is an established therapy for medically…Deep brain stimulation in the STN of a Parkinsonian rat model overexpressing human A53T α-synuclein in the substantia nigra – A proof of principle
Objective: To determine if subthalamic nucleus (STN)-deep brain stimulation (DBS) leads to a measurable functional improvement of motor deficits in an AAV1/2 A53T α-synuclein (aSyn)…In vivo validation of a new wireless portable stimulator for chronic deep brain stimulation in freely moving rats
Objective: To develop a new dedicated stimulator, adapted for chronic experiments on rodent models and that mimics the conditions of DBS human therapy: bilateral, current-controlled…Effectiveness and micro-electrodes findings of deep brain stimulation of the STN via a parietal approach in post-infectious previously implanted Parkinson´s patients
Objective: To report our experience with an alternative entry point to access STN in the treatment of Parkinson's disease (PD) and its micro-electrodes findings. Background:…The subthalamic nucleus activity during gait in Parkinson’s disease
Objective: To investigate the activity of the subthalamic nucleus (STN) during gait in subjects with Parkinson's disease (PD). Background: Gait disturbance is a key component…Surgical replacement of implantable pulse generators in deep brain stimulation: Adverse events and risk factors in a multicenter cohort
Objective: To investigate the incidence of adverse events and postoperative infections of IPG replacements in a multicenter cohort. Background: Deep brain stimulation (DBS) is a…High voltage stimulation of the VIM thalamus mimicking PSP in a patient with ET + PD
Objective: To report a case of an 81 year-old male with ventral intermediate nucleus (VIM) deep brain stimulation (DBS) for essential tremor (ET) who developed…
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