Levodopa responsiveness in Parkinson’s disease is significantly impaired in those with diabetes and increased vascular risk.
Objective: To define variation in L-dopa response in recent onset PD. Background: L-Dopa responsiveness is a defining feature of Parkinson’s disease (PD), but the degree…Effect of Droxidopa Treatment on Fear of Falling in Patients With Neurogenic Orthostatic Hypotension: Clinical Trial and “Real World” Results
Objective: To assess the impact of droxidopa on fear of falling in patients with symptomatic neurogenic orthostatic hypotension (nOH) in 2 studies. Background: nOH results…Motor stress elicits dystonia-like movements in a pharmacological mouse model for Rapid-Onset Dystonia-Parkinsonism (DYT12)
Objective: To study if a mild stressful trigger by motor activity leads to development of dystonia-like movements in a pharmacological mouse model for DYT12. Background:…Research on Relationship between Sensory Tricks of Cervical Dystonia and Function of Cerebral Cortex
Objective: To investigate demography of sensory tricks in cervical dystonia, to discuss relationship between sensory tricks and function of sensorimotor integration in supplementary motor area of…Associations between Functional Networks and Temporal Discrimination Thresholds in Cervical Dystonia patients and their unaffected relatives
Objective: To investigate resting state functional networks across cervical dystonia patients and their unaffected relatives with and without abnormal temporal discrimination thresholds (TDTs) based on…Treatment of back pain in patient with extensor truncal dystonia with lumbar radiofrequency ablation (RFA)
Objective: Extensor truncal dystonia in majority of cases leads to significant low, mid back pain and discomfort secondary to muscle spasms and early degenerative spinal…Disease modeling for Perry syndrome using patient induced pluripotent stem cells
Objective: To develop a novel model of Perry syndrome using induced pluripotent stem cell (iPSC)-derived neurons. Background: Perry syndrome is a rare autosomal dominant disorder…3D image as a complimentary assist in patients with Parkinson’s disease
Objective: To assist patients with PD to overcome the fear of stair ascent and descent with help of 3D effect staircase Background: Since walking on…Effect of object size and obstacle avoidance on of Reach-to-Grasp Actions in Individuals with Parkinson’s disease
Objective: To investigate the effect of object size and obstacle on reach-to-grasp (RTG) actions in individuals Parkinson's disease (PD). Background: Previous studies reported impairments of…Double-blind, randomized, placebo-controlled, Phase III study (TOLEDO) to evaluate the efficacy of apomorphine subcutaneous infusion in reducing OFF time in Parkinson’s disease patients with motor fluctuations not well controlled on optimized conventional treatment
Objective: The TOLEDO Study (NCT02006121) is a prospective, randomized, multicenter, double-blind, Phase III trial undertaken to investigate the efficacy of apomorphine subcutaneous infusion (APO) compared…
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