Early caudate involvement in Parkinson’s disease may predict future cognitive decline
Objective: 1. To investigate prevalence of caudate dopaminergic dysfunction as measured by 123I-FP-CIT in a large cohort of early stage (< 2 years disease duration)…Altered Resting-State Functional Interhemispheric Connectivity in Parkinson’s Disease
Objective: To examine direct interhemispheric functional connectivity (FCi) in Parkinson's disease (PD) during resting-state fMRI and to investigate the relations between observed connectivity changes and…Assessing cholinergic innervation in Parkinson’s disease using the PET imaging marker [18F]Fluoroethoxybenzovesamicol
Objective: To validate [18F]Fluoroethoxybenzovesamicol ([18F]FEOBV) imaging in healthy volunteers by dynamic scanning. The secondary objective of this study was to evaluate the differences in [18F]FEOBV binding…Non-motor symptom burden is associated with thalamic atrophy in Parkinson’s disease
Objective: To investigate whether non-motor symptoms burden is associated with cortical and subcortical morphological changes in PD patients. Background: Non-motor symptoms are common aspects of…Pilot evaluation of pseudoelastic orthoses for supporting motor control in children with secondary dystonia and dyskinesia
Objective: The study reports preliminary observations on the use of orthotic devices with nonlinear spring properties prescribed with the aim to stabilise posture and improve…First Report of Clinical Outcomes Resulting from Use of Directional Deep Brain Stimulation in Parkinson’s Disease and Essential Tremor
Objective: To evaluate clinical motor outcomes, the patient´s subjectively perceived benefit and the frequency of the use of directional lead stimulation in subjects with Essential tremor…Tremor as the first symptom reported by Parkinson’s disease patients is a predictor of future motor subtype and levodopa-induced dyskinesia.
Objective: To better delineate risk profiles for the development of levodopa-induced dyskinesia is an important effort that can help understand this phenomenon and could impact…MDS prodromal PD research criteria validation in two independent prospective cohorts
Objective: To evaluate the Movement Disorder Society prodromal Parkinson's disease criteria to two independent longitudinal studies Background: The MDS research criteria for prodromal Parkinson’s disease (PD)…Dr. Paula Coutinho’s Seminal Contributions to the Understanding of Machado-Joseph’s Disease
Objective: To recognize the contributions of Dr. Paula Coutinho to Neurology through her studies of Machado-Joseph’s disease (SCA3) Background: One of the unique opportunities in…The Superior Colliculus is impaired in de novo Parkinson’s disease patients
Objective: To study the function of the Superior Colliculus (SC) in de novo Parkinson’s disease (PD) patients. Background: The SC function is impaired in parkinsonian…
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