a-synuclein neurotoxicity and spreading using Lewy Body extracts from Parkinson Disease Brains: In vitro screening by cell-based assays
Objective: To define the kinetics of neuronal and astrocytic abnormalities induced by human-derived α-syn aggregates for grounding the use of such system to identify and…Detection of Early Changes in Microbiota Composition in Prodromal Parkinson’s Disease
Objective: To identify predictive markers of Parkinson’s disease (PD) in the gut microbiota composition of subjects at risk for developing PD due to a positive…Alpha-synuclein protein homeostasis and oligomerization in iron-overloaded cells expressing mutant HFE
Objective: Study the direct and indirect effects of iron overload on alpha synuclein homeostasis in a genetic model of hemochromatosis (HFE) Background: Parkinson’s disease (PD)…FXTAS, PD, and ET subjects demonstrate distinct gait, balance and tremor deficits under normal, environmentally challenging, and dual-task conditions
Objective: To compare FXTAS, PD, ET and controls using quantitative measures of gait, balance, and tremor. Background: Fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disease…Familial idiopathic basal ganglia calcification with novel SLC20A2 gene variant
Objective: Describe a family with brain calcifications related to new pathogenic variant of SLC20A2 gene. Background: Three genes are associated with the rare occurrence of autosomal…Assessing Parkinson’s disease motor symptoms using supervised learning algorithms
Objective: Implantable brain stimulators are now an established method of treating Parkinson’s Disease (PD). Determination of optimal neural stimulation parameters is complex and clinically demanding. The goal of…Final validation of an electronic diary for motor fluctuations and dyskinesias evaluation in PD patients: Comparison with paperback diary.
Objective: To determine the reliability and compliance to an electronic motor diary in PD patients. Background: Despite paper diaries are widely used, adherence, duplication, fraudulent…Direct dopaminergic responsiveness of activity performance
Objective: To assess the direct dopaminergic responsiveness of motor and process aspects of activity performance in people with parkinsonian disorders, and to compare this to…Comparison of neurotoxic potency of a newly produced Botulinum Neurotoxin Type A with onabotulinumtoxinA, incobotulinumtoxinA and BotulinumtoxinA
Objective: This study aims to compare the neurotoxic potency of four different kinds of toxins, accompanied with expression level changes of key factors after BoNT/A…Inhaling xenon ameliorates L-DOPA-induced dyskinesia in Parkinson disease through normalizing maladaptive corticostriatal plasticity
Objective: To investigate the mechanism(s) of action of xenon inhalation for the treatment of L-DOPA-induced dyskinesia. Background: L-dopa-induced dyskinesia (LID) is one of the most…
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