Deutetrabenazine is Associated with an Improvement in Involuntary Movements in Patients With Tardive Dyskinesia as Seen by the High Proportion of Responders to Deutetrabenazine Treatment in the AIM-TD Study
Objective: To examine response rates between patients receiving deutetrabenazine and placebo. Response levels were pre-specified from 10–90% improvement from baseline in Abnormal Involuntary Movement Scale…Laryngeal Tardive Dyskinesia in a Patient treated with Haldol
Objective: To describe the case of woman with post stroke hemiballism treated chronically with Haldol who developed laryngeal tardive dystonia and to review the current…Glucocerebrosidase mutations in idiopathic REM sleep disorder
Objective: Several studies have shown that glucocerebrosidase gene (GBA) mutations are strongly associated with the development of Lewy body diseases (LBD) and that idopathic REM…The neural correlates of apathy in premanifest and manifest Huntington’s disease: A cross-sectional multimodal imaging study
Objective: To delineate the brain correlates of apathy severity by means of glucose metabolism (18-FDG PET), grey-matter (GM) and white-matter (WM; FA-DTI) changes and relations…Update on the MDS-Sponsored Systematic Review On Clinical Rating Scales for Huntington’s Disease: motor, cognitive, functional ability and quality of life domains
Objective: To provide an update on the MDS-sponsored Systematic Review of Rating Scales for Huntington’s Disease (HD). Background: The use and validity of clinical rating…Baseline multimodal information predicts future motor impairment in premanifest Huntington’s disease
Objective: To evaluate the prognostic accuracy of structural magnetic resonance imaging and genetic-based measures in premanifest Huntington’s disease for estimating future motor impairment. Background: Despite…Mutant DNAJC13 modulates accumulation and toxicity of alpha-synuclein through altered endosomal trafficking in cell and fly models of Parkinson’s disease
Objective: The aim of this study is to investigate the effect of DNAJC13 mutation on the vesicle transport, α-synuclein (αSYN) distribution/catabolism, and neurodegeneration using a…Brain insulin resistance in Parkinson’s disease
Objective: To test the hypothesis that brain insulin resistance (i.e. decreased insulin/insulin like growth factor (IGF)-1 signaling) occurs in the substantia nigra pars compacta (SNc)…Reproducibility of data-driven Parkinson’s disease subtypes for clinical research using a Delphi process for expert-based consensus.
Objective: To assess reproducibility of published data-driven PD subtype classification systems. Background: There is no consensus on which is the most robust PD subtype classification…The value of the Tau/α-synuclein ratio and TNF-α in cerebrospinal fluid, and of plasma IL-6, in the diagnosis and prognosis of Parkinson’s disease
Objective: To evaluate cerebrospinal fluid (CSF) levels of proteins associated with neuropathological inclusions and ratios among them and CSF and plasma levels of inflammation-related proteins…
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