Mechanisms of sub-anesthetic ketamine infusions to reduce L-DOPA-induced dyskinesia: effects on striatal mTOR signaling and beta band oscillations in striatum and motor cortex
Objective: To evaluate mechanism of long-term activity of sub-anesthetic ketamine infusion to reduce L-DOPA-induced dyskinesia (LID). Background: We have published preclinical evidence and patient case…Study of neuroprotective effects of Ginsenside Rg3 , the prototypal epigenetic Sirtuin-1 activator, in targeting microglia activation and neurotrophic factor (NF) neural plasticity in MPTP model of Parkinson’s disease (PD)
Objective: 1) to examine whether the phyto-neurosteroid: Ginsenoside Rg3 recently demonstrated to activate the epigenetic SIRTI signaling, will rescue the motor impairment in rodent model…Development and validation of an alternative version of the Parkinson’s Disease-Cognitive Rating Scale
Objective: To develop and validate an alternative form of the PD-CRS (PD-CRS/AF) with the objective of providing a reliable and fully equivalent method of reassessment…The Effects of Contingency-based Musical Gait Feedback on Cognition in Individuals with Parkinson’s disease: An Interim Analysis
Objective: To investigate the effects of a 12-week home-based musical gait feedback program on cognition in persons with Parkinson’s disease (PD). Background: Individuals with PD…Defective visual perception in patients with Lewy body disease: assessment of hallucinations with pareidolia test.
Objective: Hallucination is a common feature in patients with advanced Parkinson’s disease(PD) and dementia with Lewy bodies (DLB). Background: The pareidolia test is a tool…Apolipoprotein E ε4 allele frequency in Korean Patients with Parkinson’s disease Dementia
Objective: The Apo E allele frequencies were evaluated in Korean patients with probable PDD diagnosed by the MDS task force criteria for the diagnosis of…The Effect of Anxiety on Cognition in Parkinson’s Disease
Objective: Our study examined the effect of anxiety on cognition in Parkinson’s disease (PD) patients without cognitive impairment, mild cognitive impairment and dementia. Background: Anxiety…CLOCK rs1801260 polymorphism is associated with suscepibilty of Parkinson’s disease in Chinese population
Objective: This study is aimed at evaluating the potential association between the single-nucleotide polymorphism of two functional clock genes (CLOCK gene rs1801260 and PER2 gene…Alteration of early endosomal trafficking causes neurodegeneration in PARK20
Objective: To elucidate the molecular basis of the Park20 by evaluating the role of synaptojanin 1 in intracellular trafficking. Background: Recently a new form of…Full sequencing and GWAS markers analysis of SNCA in RBD and progression to synucleinopathies.
Objective: To study the role of SNCA variants in REM sleep Behavior Disorder (RBD) and progression to synucleinopathies. Background: Individuals with properly diagnosed idiopathic RBD…
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