Association of CSF biomarkers with motor and non-motor features in moderately advanced Parkinson’s disease cohort: the BioFIND study
Objective: Evaluate associations between CSF biomarkers of neurodegeneration and clinical phenotype in Parkinson’s disease (PD) participants of the BioFIND cohort. Background: Levels of CSF α-synuclein…Dural lymphatic vasculature in human superior saggital sinus: the brain drain
Objective: To provide independent validation in human dura obtained at autopsy of the reported presence of dural lymphatic vessels. Background: Two recent studies have challenged…Deep Brain Stimulation (DBS) battery longevity of Medtronic Activa SC is briefer than preceding Soletra models, a within subject analysis
Objective: To contrast the durations of Activa SCs with the durations of preceding Soletra neurostimulator models within the same individuals programmed at near constant parameters.…Development of a Paroxysmal Movement Disorder Diary for Patients with Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)
Objective: To perform qualitative research to develop and establish content validity of a new clinical outcome assessment (COA) instrument for paroxysmal movement disorders in Glut1…Spg 11 gene mutation associated autosomal recessive hereditary spastic paraplegia presenting with partially levodopa responsive parkinsonism, stereotypy and cognitive decline.
Objective: To describe a rare case of SPG11 gene mutation associated complex hereditary spastic paraplegia with partially levodopa responsive parkinsonism Background: Hereditary Spastic Paraplegia (HSP)…The AppTUG : a new application for analyzing the Timed Up and Go task in patients with neurological disorders
Objective: To perform an initial validation of a newly developed smartphone-based Timed Up & Go (TUG) application (AppTUG), by comparing its measurements to the stopwatch-measured…Objective Measurement in Clinical Care of Patients with Parkinson’s disease: an RCT using the PKG
Objective: To use the Parkinson’s KinetiGraph™ (Global Kinetics CorporationTM, Australia) to help identify uncontrolled Parkinson’s disease (PD) symptoms and assist changes in clinical management leading…An Evaluation of the Parkinson’s Kinetigraph (PKG) as a Tool to Support Deep Brain Stimulation Eligibility Assessment in Patients with Parkinson’s Disease
Objective: To assess whether data obtained from an objective movement recording system such as the Parkinson’s KinetiGraph (PKG) could predict the motor criteria used by…CB2R agonist AM1241 reverses the development of MPTP-induced PD and activates the regeneration of DA neurons
Objective: A promising and potential direction to treat PD is to develop new non-dopaminergic drugs without producing dyskinesia, as well as arresting and even reversing…Exercise Trends Reported in Parkinson’s Patients
Objective: To examine trends in type, frequency, and effectiveness of exercise in Parkinson’s patients based on gender, race, and years since diagnosis. Background: Exercise has…
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